Research Output 1988 2019

14-3-3{zeta} coordinates adipogenesis of visceral fat

Lim, G., Albrecht, T., Piske, M., Sarai, K., Lee, J. T. C., Ramshaw, H. S., Sinha, S., Guthridge, M. A., Acker-Palmer, A., Lopez, A. F., Clee, S. M., Nislow, C. & Johnson, J. D., 2015, In : Nature Communications. 6, (Art. No: 7671), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J. M., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., Van Der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 othersJackson, S. P., 27 Sep 2016, In : Nature Communications. 7, 17 p., 12862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: An analogue of platelet-activating factor with partial agonist activity

Grigoriadis, G. & Stewart, A. G., 1991, In : British Journal of Pharmacology. 104, 1, p. 171 - 177 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aberrant bone formation in mice over-expressing specific VEGF isoforms in cartilage.

Maes, C., Haigh, J., Chan, A., Haigh, K., Bouillon, R., Carmeliet, G. & Nagy, A., 2005, In : Journal of Bone and Mineral Research. 20, 9, p. 39 1 p.

Research output: Contribution to journalArticleResearch

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

Salmon, J., Slater, N., Hall, M., McCormack, M., Jane, S. & Curtis, D., 2007, In : Blood. 110, 10, p. 3573 - 3581 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D., Wang, H., Johnston, L., Daglas, M., Ates, R. C., Medcalf, R. L., Taylor, J. M. & Crack, P. J., 1 Jan 2016, In : eNeuro. 3, 1, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A brief history of blood platelets: A personal view

Berndt, M. C., Metharom, P. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Gresele, P., Kleiman, N. S., Lopez, J. A. & Page, C. P. (eds.). Cham: Springer, p. 3-10 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract B39: PTP1B deficiency potentiate prostate cancer invasiveness by sensitizing Pten-null tumors to high-fat diet

Labbé, D. P., Uetani, N., Vinette, V., Aubry, I., Migon, E., Sirois, J., Haigh, J. J., Lessard, L., Bégin, L. R., Trotman, L. C., Paquet, M. & Tremblay, M. L., 2016, In : Molecular Cancer Research. 14, 1 Supplement, p. B39 1 p.

Research output: Contribution to journalArticleOtherpeer-review

A case of ITP with cauda equina syndrome

Merriman, E., Nandurkar, D., Opat, S. & Tran, H., Jun 2011, In : Annals of Hematology. 90, 6, p. 729-730 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Accelerating Early Drug Development: Come on Down Under

Wei, A., Jul 2017, In : Annals of Oncology. 28, 7, p. 1655-1657 3 p., mdx101.

Research output: Contribution to journalArticleOtherpeer-review

A comparison of global coagulation assays between normal controls and patients with thrombocytopenia

Lim, H. Y., Leung, P., Manitta, V., Nandurkar, H. & Ho, P., 1 Apr 2019, In : International Journal of Laboratory Hematology. 41, 2, p. 184-191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A comparison of the efficacy of immunomodulatory-free regimens in relapsed or refractory multiple myeloma: a network meta-analysis

Weisel, K., Sonneveld, P., Spencer, A., Beksac, M., Rizzo, M., Xu, Y., Fahrbach, K., Gaudig, M., Slavcev, M., Dearden, L. & Lam, A., 1 Jan 2019, In : Leukemia and Lymphoma. 60, 19, p. 151–162 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S. L., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P., Jane, S. M. & Curtis, D. J., 2006, In : Blood. 108, 7, p. 2248-2256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells

Haigh, J. J., Ema, M., Haigh, K., Gertsenstein, M., Greer, P., Rossant, J., Nagy, A. & Wagner, E. F., 2004, In : Blood. 103, 3, p. 912-920 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Smith, A. M., Dun, M. D., Lee, E. M., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A. S., Morris, J., Toop, H., Lock, R. B., Powell, J. A., Thomas, D., Guthridge, M. A., Moore, A., Ashman, L. K., Skelding, K. A., Enjeti, A. & Verrills, N. M., 2016, In : Oncotarget. 7, 30, p. 47465-47478 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast

Pollheimer, J., Loregger, T., Sonderegger, S. E., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K., Husslein, P. & Knofler, M., 2006, In : American Journal of Pathology. 168, 4, p. 1134 - 1147 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

ADAMTS13 antibody depletion by bortezomib in thrombotic thrombocytopenic purpura

Shortt, J., Oh, D. H. & Opat, S., 2013, In : New England Journal of Medicine. 368, 1, p. 90 - 92 3 p.

Research output: Contribution to journalLetterOther

Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals

Sturgeon, S. A., Jones, C., Angus, J. A. & Wright, C. E., 2006, In : Journal of Pharmacological and Toxicological Methods. 53, 1, p. 20 - 29 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein ibalpha

Kruss, S., Erpenbeck, L., Amschler, K., Mundinger, T. A., Boehm, H., Helms, H. J., Friede, T., Andrews, R. K., Schon, M. & Spatz, J. P., 2013, In : ACS Nano. 7, 11, p. 9984 - 9996 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Adhesion of circulating leukocytes and platelets to the vessel wall

Cranmer, S. L. & Nash, G. B., 2007, Handbook of Hemorrheology and Hemodynamics. Baskurt, O. K., Hardeman, M. R., Rampling, M. W. & Meiselman, H. J. (eds.). The Netherlands: IOS Press, p. 153 - 169 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets

Facey, A. D., Pinar, I., Arthur, J. F., Qiao, J. L., Jing, J., Mado, B., Carberry, J. J., Andrews, R. K. & Gardiner, E. E., 2016, In : Biochemistry. 55, 8, p. 1187 - 1194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival

Souroullas, G., Salmon, J. M., Sablitzky, F., Curtis, D. J. & Goodell, M. A., 2009, In : Cell Stem Cell. 4, 2, p. 180 - 186 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair, A. P., Walker, P., Kalff, A., Bergin, K., Hocking, J., Avery, S., Curtis, D. J., Patil, S., Das, T., Klarica, D., Morgan, S., Muirhead, J., Gorniak, M. B., Reynolds, J. & Spencer, A., 1 Jun 2017, In : Bone Marrow Transplantation. 52, 6, p. 839-845 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler, D. F., Madondo, M. T., Hanafi, G., Plebanski, M. & Medcalf, R. L., 1 Apr 2017, In : Cytometry Part A. 91, 4, p. 336-350 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A functional 14-3-3{zeta}-independent association of PI3-kinase with glycoprotein Ib{alpha}, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

Mu, F-T., Andrews, R. K., Arthur, J. F., Munday, A. D., Cranmer, S. L., Jackson, S., Stomski, F. C., Lopez, A. F. & Berndt, M. C., 2008, In : Blood. 111, 9, p. 4580 - 4587 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant

French, S. L., Thalmann, C., Bray, P. F., Macdonald, L. E., Murphy, A. J., Sleeman, M. W. & Hamilton, J. R., 12 Jun 2018, In : Blood Advances. 2, 11, p. 1283-1293 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A global role for EKLF in definitive and primitive hematopoiesis

Perkins, A. C., 2006, In : Blood.

Research output: Contribution to journalArticleResearchpeer-review

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model

Gaspari, T., Liu, H., Welungoda, I., Hu, Y., Widdop, R., Knudsen, L., Simpson, R. & Dear, A., 2011, In : Diabetes and Vascular Disease Research. 8, 2, p. 117 - 124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A GPIb-IX-V complex signaling environment

Gardiner, E., 2010, In : Journal of Thrombosis and Haemostasis. 8, 5, p. 1075 - 1076 2 p.

Research output: Contribution to journalLetterOther

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Bouhy, D., Juneja, M., Katona, I., Holmgren, A., Asselbergh, B., De Winter, V., Hochepied, T., Goossens, S., Haigh, J. J., Libert, C., Ceuterick-de Groote, C., Irobi, J., Weis, J. & Timmerman, V., Jan 2018, In : Acta Neuropathologica. 135, 1, p. 131–148 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B., Guthridge, M. A., Pearson, R. B. & Ekert, P. G., 2013, In : Cell Death and Differentiation. 20, 10, p. 1341 - 1349 9 p.

Research output: Contribution to journalArticleResearchpeer-review

AKT Isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans

Haslinger, P., Haidar, S., Sonderegger, S. E., Otten, J. V., Pollheimer, J., Whitley, G. & Knofler, M., 2013, In : Biology of Reproduction. 88, 3, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Albumin inhibits platelet-activating factor (PAF)-induced responses in platelets and macrophages: Implications for the biologically active form of PAF

Grigoriadis, G. & Stewart, A. G., 1992, In : British Journal of Pharmacology. 107, 1, p. 73 - 77 5 p.

Research output: Contribution to journalArticleResearchpeer-review

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt, W. S., Harper, I. S., Schoenwaelder, S. M., Yuan, Y. & Jackson, S. P., 2012, In : Methods in Molecular Biology. 788, p. 73 - 89 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue

Tjarnlund-Wolf, A., Hultman, K., Curtis, M., Faull, R., Medcalf, R. & Jern, C., 2011, In : Thrombosis and Haemostasis. 105, 6, p. 945 - 953 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules

Liu, H. B., Dear, A. E., Knudsen, L. B. & Simpson, R., 2009, In : Journal of Endocrinology. 201, 1, p. 59 - 66 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y-P., Schwarz, M., Hagemeyer, C. E., Eisenhardt, S. U., Ahrens, I., Bode, C., Jackson, S. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 3, p. 9 - 15 7 p.

Research output: Contribution to journalArticleResearchpeer-review

AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies

Caenepeel, S., Brown, S. P., Belmontes, B., Moody, G., Keegan, K. S., Chui, D., Whittington, D. A., Huang, X., Poppe, L., Cheng, A. C., Cardozo, M., Houze, J., Li, Y., Lucas, B., Paras, N. A., Wang, X., Taygerly, J. P., Vimolratana, M., Zancanella, M., Zhu, L. & 18 othersCajulis, E., Osgood, T., Sun, J., Damon, L., Egan, R. K., Greninger, P., McClanaghan, J. D., Gong, J., Moujalled, D., Pomilio, G., Beltran, P., Benes, C. H., Roberts, A. W., Huang, D. C., Wei, A., Canon, J., Coxon, A. & Hughes, P. E., 1 Dec 2018, In : Cancer Discovery. 8, 12, p. 1582-1597 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2010, In : Lab on a Chip. 10, 3, p. 291 - 302 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J., 1 Aug 2017, In : Disease Models and Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A multi-centre, single-arm, open-label study evaluating the safety and efficacy of fixed dose rituximab in patients with refractory, relapsed or chronic idiopathic thrombocytopenic purpura (R-ITP1000 study)

Tran, H. A., Brighton, T., Grigg, A. P., McRae, S., Dixon, J., Thurley, D., Gandhi, M. K., Truman, M., Marlton, P. & Catalano, J., 2014, In : British Journal of Haematology. 167, 2, p. 243 - 251 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

Nesbitt, W. S., Tovar-Lopez, F. J., Westein, E., Harper, I. S. & Jackson, S., 2013, Adhesion Protein Protocols. Coutts, A. S. (ed.). USA: Humana Press, Vol. 1046. p. 39 - 58 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

An acquired defect associated with abnormal signaling of the platelet collagen receptor glycoprotein VI

Qiao, J. L., Arthur, J. F., Collecutt, M., Shen, Y., Mu, F-T., Berndt, M. C., Davis, A., Andrews, R. K. & Gardiner, E. E., 2012, In : Acta Haematologica. 128, 4, p. 233 - 241 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity

Abbott, B. & Thompson, P. E., 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 4, p. 969 - 973 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of circulating tumor DNA

Mithraprabhu, S. & Spencer, A., 1 Jan 2018, Methods in Molecular Biology. Humana Press, p. 129-145 17 p. (Methods in Molecular Biology; vol. 1792).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Analysis of histone modifications in acute myeloid leukaemia using chromatin immunoprecipitation

Shields, B. J., Keniry, A., Blewitt, M. E. & McCormack, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York : Humana Press, p. 177-184 8 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Lindemann, R. K., Newbold, A., Whitecross, K. F., Cluse, L. A., Frew, A. J., Ellis, L., Williams, S., Wiegmans, A. P., Dear, A. E., Scott, C. L., Pellegrini, M., Wei, A., Richon, V. M., Marks, P. A., Lowe, S. W., Smyth, M. J. & Johnstone, R. W., 2007, In : Proceedings of the National Academy of Sciences. 104, 19, p. 8071 - 8076 6 p.

Research output: Contribution to journalArticleResearchpeer-review