Research Output 1981 2019

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2018

Mutant NR5A1/SF-1 in patients with disorders of sex development shows defective activation of the SOX9 TESCO enhancer

Sreenivasan, R., Ludbrook, L. M., Fisher, B. D., Declosmenil, F., Knower, K. C., Croft, B. M., Bird, A. D., Ryan, J., Bashamboo, A., Sinclair, A., Koopman, P., McElreavey, K., Poulat, F. & Harley, V. R., 1 Dec 2018, In : Human Mutation. 39, 12, p. 1861-1874 14 p.

Research output: Contribution to journalArticleResearchpeer-review

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Anderson, D. J., Kaplan, D. I., Bell, K. M., Koutsis, K., Haynes, J. M., Mills, R. J., Phelan, D. G., Qian, E. L., Leitoguinho, A. R., Arasaratnam, D., Labonne, T., Ng, E. S., Davis, R. P., Casini, S., Passier, R., Hudson, J. E., Porrello, E. R., Costa, M. W., Rafii, A., Curl, C. L. & 9 othersDelbridge, L. M., Harvey, R. P., Oshlack, A., Cheung, M. M., Mummery, C. L., Petrou, S., Elefanty, A. G., Stanley, E. G. & Elliott, D. A., 10 Apr 2018, In : Nature Communications. 9, 1, 13 p., 1373.

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NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., Penington, J. S., Harapas, C. R., Souza-Fonseca-Guimaraes, F., Wockner, L. F., Preaudet, A., Mielke, L. A., Wilcox, S. A., Ogura, Y., Corr, S. C., Kanojia, K., Kouremenos, K. A., De Souza, D. P., McConville, M. J., Flavell, R. A. & 6 othersGerlic, M., Kile, B. T., Papenfuss, A. T., Putoczki, T. L., Radford-Smith, G. L. & Masters, S. L., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3728.

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Novel imaging of the prostate reveals spontaneous gland contraction and excretory duct quiescence together with different drug effects

Kügler, R., Mietens, A., Seidensticker, M., Tasch, S., Wagenlehner, F. M., Kaschtanow, A., Tjahjono, Y., Tomczyk, C. U., Beyer, D., Risbridger, G. P., Exintaris, B., Ellem, S. J. & Middendorff, R., 1 Mar 2018, In : FASEB Journal. 32, 3, p. 1130-1138 9 p.

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Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells

Guttmann, S., Chandhok, G., Groba, S. R., Niemietz, C., Sauer, V., Gomes, A., Ciarimboli, G., Karst, U., Zibert, A. & Schmidt, H. H., 1 Jan 2018, In : Oncotarget. 9, 1, p. 743-754 12 p.

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Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 othersHuglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenotype and influx kinetics of leukocytes and inflammatory cytokine production in kidney ischemia/reperfusion injury

Williams, T. M., Wise, A. F., Layton, D. S. & Ricardo, S. D., 1 Jan 2018, In : Nephrology. 23, 1, p. 75-85 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?

Kara, D., Hüsing-Kabar, A., Schmidt, H., Grünewald, I., Chandhok, G., Maschmeier, M. & Kabar, I., 1 Aug 2018, In : Canadian Journal of Gastroenterology and Hepatology. 2018, 7 p., 2182784.

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Proteomic characterisation of Caenorhabditis elegans larval development

Xia, T., Horton, E. R., Salcini, A. E., Pocock, R., Cox, T. R. & Erler, J. R., Jan 2018, In : Proteomics. 18, 2, 16 p., 1700238.

Research output: Contribution to journalArticleResearchpeer-review

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Jiao, Y., Davis, J. E., Rautela, J., Carrington, E. M., Ludford-Menting, M. J., Goh, W., Delconte, R. B., Souza-Fonseca-Guimaraes, F., Koldej, R., Gray, D., Huang, D., Kile, B. T., Lew, A. M., Ritchie, D. S. & Huntington, N. D., 12 Nov 2018, In : Cell Death and Differentiation. 26, p. 1516-1530 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Stringer, J., Forster, S., Qu, Z., Prokopuk, L. A., O'Bryan, M. K., Gardner, D. K., White, S., Adelson, D. L. & Western, P. S., 20 Sep 2018, In : BMC Biology. 16, 20 p., 104.

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Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges

Dando, S. J., Kazanis, R., Chinnery, H. R. & McMenamin, P. G., 26 Dec 2018, (Accepted/In press) In : GLIA. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of activin C in normal ovaries and granulosa cell tumours of mice and humans

Reader, K. L., Marino, F. E., Nicholson, H. D., Risbridger, G. P. & Gold, E. J., 1 Jan 2018, In : Reproduction, Fertility and Development. 30, 7, p. 958-968 11 p., RD17250.

Research output: Contribution to journalArticleResearchpeer-review

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Sex determination and gonadal sex differentiation in the chicken model

Hirst, C. E., Major, A. T. & Smith, C. A., 1 Jan 2018, In : International Journal of Developmental Biology. 62, 1-3, p. 153-166 14 p.

Research output: Contribution to journalArticleResearchpeer-review

SRSF3 promotes pluripotency through nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L., 9 May 2018, In : eLife. 7, 28 p., e37419.

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Structure, function, and regulation of mitofusin-2 in health and disease

Chandhok, G., Lazarou, M. & Neumann, B., 1 May 2018, In : Biological Reviews. 93, 2, p. 933-949 17 p.

Research output: Contribution to journalArticleOtherpeer-review

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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Grabow, S., Kueh, A. J., Ke, F., Vanyai, H. K., Sheikh, B. N., Dengler, M. A., Chiang, W., Eccles, S., Smyth, I. M., Jones, L. K., De Sauvage, F. J., Scott, M., Whitehead, L., Voss, A. K. & Strasser, A., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3285-3295 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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Sustained cardiac programming by short-term juvenile exercise training in male rats

Asif, Y., Wlodek, M. E., Black, M. J., Russell, A. P., Soeding, P. F. & Wadley, G. D., 15 Jan 2018, In : Journal of Physiology. 596, 2, p. 163-180 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Technical Note: The use of 3D printing in dental anthropology collections

Fiorenza, L., Yong, R., Ranjitkar, S., Huges, T., Quayle, M., McMenamin, P. G., Kaidonis, J., Townsend, G. C. & Adams, J. W., Oct 2018, In : American Journal of Physical Anthropology. 167, 2, p. 400-406 7 p.

Research output: Contribution to journalArticleResearchpeer-review

TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor, W. A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T. J., Lukianchikov, A., Liu, X., Polo, J. M., Jacobsen, S. E. & Clark, A. T., 1 May 2018, In : Nature Cell Biology. 20, 5, p. 553-564 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The antidepressant fluoxetine alters mechanisms of pre- and post-copulatory sexual selection in the eastern mosquitofish (Gambusia holbrooki)

Bertram, M. G., Ecker, T. E., Wong, B. B. M., O'Bryan, M. K., Baumgartner, J. B., Martin, J. M. & Saaristo, M., 1 Jul 2018, In : Environmental Pollution. 238, p. 238-247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The effect of sex and prematurity on the cardiovascular baroreflex response in sheep

Allison, B. J., Nguyen, V. B., Yiallourou, S., Nitsos, I., Black, M. J. & Polglase, G., 1 Jan 2018, In : Experimental Physiology. 103, 1, p. 9-18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The functional anatomy of external genitalia in the black tiger prawn (Penaeus monodon) studied by micro-computed tomography and scanning electron microscopy

Tianyi, F., Paterson, B., Panagiotopoulou, O., Green, K., Mardon, K. & Johnston, S., Sep 2018, In : Journal of Morphology. 279, 9, p. 1346-1354 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

Vince, J. E., De Nardo, D., Gao, W., Vince, A. J., Hall, C., McArthur, K., Simpson, D., Vijayaraj, S., Lindqvist, L. M., Bouillet, P., Rizzacasa, M. A., Man, S. M., Silke, J., Masters, S. L., Lessene, G., Huang, D. C. S., Gray, D. H. D., Kile, B. T., Shao, F. & Lawlor, K. E., 27 Nov 2018, In : Cell Reports. 25, 9, p. 2339-2353 15 p.

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The physiological linkage between molar inclination and dental macrowear pattern

Oxilia, G., Bortolini, E., Martini, S., Papini, A., Boggioni, M., Buti, L., Figus, C., Sorrentino, R., Townsend, G., Kaidonis, J., Fiorenza, L., Cristiani, E., Kullmer, O., Moggi-Cecchi, J. & Benazzi, S., Aug 2018, In : American Journal of Physical Anthropology. 166, 4, p. 941-951 11 p.

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The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate

Vissers, J. H. A., Froldi, F., Schroder, J., Papenfuss, A. T., Cheng, L. Y. & Harvey, K. F., 6 Nov 2018, In : Cell Reports. 25, 6, p. 1561-1576 17 p.

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The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress

Miyamoto, Y., Whiley, P. A. F., Goh, H., Wong, C. L., Tachibana, T., McMenamin, P. G., Mayne, L. & Loveland, K. A. L., 1 Jan 2018, In : Biology Open. 7, 8, 12 p., bio032631.

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The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.

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The use of targeted next generation sequencing to explore candidate regulators of TGF-β1's impact on kidney cells

Wang, B., Ji, G., Naeem, H., Wang, J., Kantharidis, P., Powell, D. & Ricardo, S. D., Dec 2018, In : Frontiers in Physiology. 9, 14 p., 1755.

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Understanding of the significance and health implications of asplenia in a cohort of patients with haemaglobinopathy: possible benefits of a spleen registry

Premawardena, C., Bowden, D., Kaplan, Z., Dendle, C. & Woolley, I. J., 2018, In : Hematology. 23, 8, p. 526-530 5 p.

Research output: Contribution to journalArticleResearchpeer-review

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Chin, H. S., Li, M. X., Tan, I. K. L., Ninnis, R. L., Reljic, B., Scicluna, K., Dagley, L. F., Sandow, J. J., Kelly, G. L., Samson, A. L., Chappaz, S., Khaw, S. L., Chang, C., Morokoff, A., Brinkmann, K., Webb, A., Hockings, C., Hall, C. M., Kueh, A. J., Ryan, M. T. & 7 othersKluck, R. M., Bouillet, P., Herold, M. J., Gray, D. H. D., Huang, D. C. S., van Delft, M. F. & Dewson, G., 26 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4976.

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Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Richardson, A. M., Lewis, D. P., Kita, B., Ludlow, H., Groome, N. P., Hedger, M. P., de Kretser, D. M. & Lidbury, B. A., 12 Apr 2018, In : Journal of Translational Medicine. 16, 1, 11 p., 97.

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Wip1 knockout inhibits neurogenesis by affecting the Wnt/β-catenin signaling pathway in focal cerebral ischemia in mice

Qiu, C. W., Liu, Z. Y., Hou, K., Liu, S. Y., Hu, Y. X., Zhang, L., Zhang, F. L., Lv, K. Y., Kang, Q., Hu, W. Y., Ma, N., Jiao, Y., Bai, W. J. & Xiao, Z. C., 1 Nov 2018, In : Experimental Neurology. 309, p. 44-53 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

O’brien, L. L., Combes, A. N., Short, K. M., Lindström, N. O., Whitney, P. H., Cullen-McEwen, L. A., Ju, A., Abdelhalim, A., Michos, O., Bertram, J. F., Smyth, I. M., Little, M. H. & McMahon, A. P., 5 Dec 2018, In : eLife. 7, 25 p., e40392.

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WNT9A is a conserved regulator of hematopoietic stem and progenitor cell development

Richter, J., Stanley, E. G., Ng, E. S., Elefanty, A. G., Traver, D. & Willert, K., 1 Feb 2018, In : Genes. 9, 2, 66.

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2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P., May 2017, In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: A cross sectional study

Lidbury, B. A., Kita, B., Lewis, D. P., Hayward, S., Ludlow, H., Hedger, M. P. & de Kretser, D. M., 16 Mar 2017, In : Journal of Translational Medicine. 15, 1, 10 p., 60.

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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P., 15 Jul 2017, In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate

Lee, S. N., Chakrabarty, B., Wittmer, B., Papargiris, M., Ryan, A., Frydenberg, M., Frydenberg, M., Lawrentschuk, N., Middendorff, R., Risbridger, G. P., Ellem, S. J. & Exintaris, B., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 10150.

Research output: Contribution to journalArticleResearchpeer-review

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Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Au, A. E., Lebois, M., Sim, S. A., Cannon, P., Corbin, J., Gangatirkar, P., Hyland, C. D., Moujalled, D., Rutgersson, A., Yassinson, F., Kile, B. T., Mason, K. D., Ng, A. P., Alexander, W. S. & Josefsson, E. C., 1 Dec 2017, In : Scientific Reports. 7, 1, 10 p., 14953.

Research output: Contribution to journalArticleResearchpeer-review

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Altered SOX9 genital tubercle enhancer region in hypospadias

Sreenivasan, R., Gordon, C. T., Benko, S., de Iongh, R., Bagheri-Fam, S., Lyonnet, S. & Harley, V., Jun 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 170, p. 28-38 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A new fossil dolphin Dilophodelphis fordycei provides insight into the evolution of supraorbital crests in platanistoidea (Mammalia, Cetacea)

Boersma, A. T., McCurry, M. R. & Pyenson, N. D., 31 May 2017, In : Royal Society Open Science. 4, 5, 27 p., 170022.

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An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment

Klein, B., Schuppe, H. -C., Bergmann, M., Hedger, M. P., Loveland, B. E. & Loveland, K. L., Jul 2017, In : Andrology. 5, 4, p. 763-770 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

Barsanti, M., Lim, J. M. C., Hun, M. L., Lister, N., Wong, K., Hammett, M. V., Lepletier, A., Boyd, R. L., Giudice, A. & Chidgey, A. P., Feb 2017, In : European Journal of Immunology. 47, 2, p. 291-304 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours

Sackmann Sala, L., Boutillon, F., Menara, G., De Goyon-Pélard, A., Leprévost, M., Codzamanian, J., Lister, N., Pencik, J., Clark, A., Cagnard, N., Bole-Feysot, C., Moriggl, R., Risbridger, G. P., Taylor, R. A., Kenner, L., Guidotti, J. E. & Goffin, V., Sep 2017, In : Journal of Pathology. 243, 1, p. 51-64 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Argon gas plasma to decontaminate and extend shelf life of milk

Ponraj, S. B., Sharp, J. A., Kanwar, J. R., Sinclair, A. J., Kviz, L., Nicholas, K. R. & Dai, X. J., 1 Nov 2017, In : Plasma Processes and Polymers. 14, 11, 8 p., 1600242.

Research output: Contribution to journalArticleResearchpeer-review