Anatomy & Developmental Biology

Establishing the role of apoptosis and mtDNA in lupus pathobiology

Kile, B.

1/12/19 → 30/11/21

Project: Research

A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

Pook, D.

6/11/19 → 5/11/24

Project: Research

A Phase 3, Randomized, Double-blind Study to Compare the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination with Lenvatinib (E7080/MK-7902) Versus Pembrolizumab and Placebo as First Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma in Cisplatin-ineligible Participants Whose Tumors Express PD-L1, and in Participants Ineligible for Any Platinum-containing Chemotherapy Regardless of PD-L1 Expression (LEAP-011)

Pook, D.

24/10/19 → 23/10/24

Project: Research

Novel bacteria as therapeutic candidates in Inflammatory Bowel Disease

Giles, E., Forster, S. & Abud, H.

1/10/19 → 30/09/20

Project: Research

A Multicenter, Open-label, Phase 1 Trial of bacTRL-IL-12 in Adult Subjects with Advanced, Treatment-Refractory Solid Tumors

Pook, D.

26/09/19 → 25/09/24

Project: Research

A Phase 2 Trial of Nivolumab plus Ipilimumab, Ipilimumab Alone, or Cabazitaxel in Men with Metastatic Castration-Resistant Prostate Cancer

Pook, D.

4/09/19 → 3/09/24

Project: Research

A real-time biomechanical study of Neanderthal anterior dentition

Fiorenza, L., Benazzi, S. & Sarig, R.

1/09/19 → 31/08/22

Project: Research

Resolving and translating communication within the prostate cancer microenvironment

Daly, R., Horvath, L. G., Taylor, R., Timpson, P., Cox, T. R., Song, J., Risbridger, G., Kench, J. G. & Jorgensen, C.

United States Department of Defense (DoD)

1/09/19 → 31/08/22

Project: Research

The cellular basis of branching morphogenesis during kidney development

Smyth, I., Combes, A., Fernandez-Gonzalez, R. & McNeill, H.

1/08/19 → 31/07/22

Project: Research

A phase 3 randomised, placebo-controlled, double-blind study of Niraparib in combination with Abiraterone acetate and Prednisone versus Abiraterone acetate and Prednisone for treatment of subjects with metastatic prostate cancer [MAGNITUDE].

Pook, D. & Baker, E.

29/07/19 → 31/12/24

Project: Research

Genetic Diversity in the collaborative cross model recapitulates miRNA mediated neurogenesis

Xiao, Z.

Apex Glory International Trading

22/07/19 → 31/12/23

Project: Research

Evo-Devo down under; Genetic regulation of wing reduction in the emu

Smith, C. & Tarbin, C.

2/07/19 → 1/07/22

Project: Research

Investigating a new regulator of cyst development in PKD

Smyth, I. & Cottle, D.

1/07/19 → 30/06/21

Project: Research

A Phase 2, single-arm study of bempegaldesleukin (NKTR-214) in combination with nivolumab in cisplatin ineligible, locally advanced or metastatic urothelial cancer patients

Pook, D.

24/06/19 → 23/06/24

Project: Research

A phase III randomized, double-blind, placebo-controlled trial of radium-223 dichloride in combination with abiraterone acetate and prednisone/prednisolone in the treatment of asymptomatic or mildly symptomatic chemotherapy-naïvepts with bone predominant metastatic castration-resistant prostate cancer (CRPC)

Pook, D.

20/06/19 → 19/06/24

Project: Research

A phase 1b, open label, multicenter study evaluating the safety and efficacy of ipatasertib in combination with rucaparib in patients with advanced breast, ovarian or prostate cancer [BO40933].

Pook, D. & Baker, E.

24/05/19 → 31/12/24

Project: Research

A Phase Iii, Multicenter, Randomized Study Of Atezolizumab (Anti−Pdl1 Antibody) In Combination With Enzalutamide Versus Enzalutamide Alone In Patients With Metastatic Castrationresistant Prostate Cancer After Failure Of An Androgen Synthesis Inhibitor And Failure Of, Ineligibility For, Or Refusal Of A Taxane Regimen

Pook, D.

20/05/19 → 19/05/24

Project: Research

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial Testing Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative To Placebo Plus Abiraterone Plus Prednisone/Prednisolone In Adult Male Patients With Asymptomatic Or Mildly Symptomatic, Previously Untreated, Metastatic Castrate-Resistant Prostate Cancer

Pook, D.

6/05/19 → 5/05/24

Project: Research

Use of brain organoids and artificial intelligence for understanding dementia

Jagadish, C., Gautam, V., Halgamuge, S., Pebay, A., Hernandez, D., Grubman, A., Dottori, M. & Ooi, L.

1/05/19 → 1/05/22

Project: Research

A Phase II trial of single agent cabozantinib in patients with locally advanced or metastatic non-clear cell renal cell carcinoma post immunotherapy or who are unsuitable for immunotherapy

Pook, D.

30/04/19 → 29/04/24

Project: Research

Denosumab and Pembrolizumab in Renal Cell Carcinoma: A Phase II Trial

Pook, D.

25/03/19 → 24/03/24

Project: Research

Characterising and inducing a protective microglia phenotype in human AD

Grubman, A., Polo, J. & Petretto, E.

Dementia Australia Research Foundation Ltd

1/03/19 → 1/03/21

Project: Research

Improve access to novel treatments and trials for advanced prostate cancer patients: Precision Oncology Program

Iddawela, M., Risbridger, G. & Shackleton, M.

1/03/19 → 29/02/20

Project: Research

New combination therapies for castration-resistant prostate cancer

Lawrence, M., Risbridger, G., Azad, A. & Taylor, R.

Victorian Cancer Agency

15/02/19 → 14/02/23

Project: Research

Investigating the origins of neuroendocrine prostate cancer

Toivanen, R., Risbridger, G., Taylor, R., Goode, D., Clouston, D. & Murphy, D.

15/02/19 → 14/02/23

Project: Research

Molecular Genetics of Human Sexual Differentiation

Harley, V.

1/01/19 → 31/12/23

Project: Research

Role of Transient Ca2+ in Transcriptional Wiring of Stem Cells

Gopal, S., Pocock, R. & Griesbeck, O.

1/01/19 → 31/12/21

Project: Research

Targeting Prostate Cancer with Maths

Lister, N., Polo, J. & Risbridger, G.

1/01/19 → 1/01/20

Project: Research

Unravelling the role of type I Interferon family in human infectious and inflammatory diseases

Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

Assessing and comparing function of brain organoids from persons with dementia and normal controls.

Jagadish, C., Dottori, M., Gautam, V., Grubman, A., Hernandez, D., Ooi, L. & Pébay, A.

1/01/19 → 31/12/19

Project: Research

Dying stem cells as a mechanism in mesenchymal stromal cell therapy

Heng, T.

1/01/19 → 31/12/21

Project: Research

How do neurons maintain their fate?

Harvey, K., Schroeder, J. & Cheng, L.

1/01/19 → 31/12/21

Project: Research

Dissecting TAF5L and TAF6L functions in embryonic stem cells, reprogramming and neurodevelopment

Das, P.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/21

Project: Research

Mitochondrial metabolism and its role in the maternal epigenome.

Carroll, J. & Adhikari, D.

1/01/19 → 31/12/22

Project: Research

MIR-1: A Conserved Gatekeeper of Protein Aggregation

Pocock, R. & Rubinsztein, D. C.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/21

Project: Research

Giving prostate cancer enough rope with supraphysiologic testosterone

Lawrence, M., Risbridger, G. & Joshua, A. M.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/21

Project: Research

CALCIUM-MEDIATED REGULATION OF STEM CELL DEVELOPMENT

Gopal, S.

Australian Research Council (ARC)

1/01/19 → 31/12/21

Project: Research

Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells

Samuel, C., Ricardo, S., Widdop, R. & Kerr, P.

1/01/19 → 31/12/21

Project: Research

Unveiling the epigenome dynamics through the pluripotency continuum

Polo, J.

Australian Research Council (ARC)

1/12/18 → 30/11/22

Project: Research

Transforming endocrine therapy for breast and prostate cancer

Tilley, W. D., Risbridger, G., Carroll, J., Lim, E., Clark, S. J., Hicky, T. & Selth, L.

1/11/18 → 31/10/21

Project: Research

Mechanisms of mesenchymal stem cell therapy

Heng, T.

8/10/18 → 8/04/22

Project: Research

Clinical development of a monoclonal antibody-based therapeutic targeting polycystic kidney disease

Ricardo, S. & Wang, B.

1/09/18 → 31/08/20

Project: Research

The Hippo signalling pathway in dividing and non-dividing cells

Harvey, K.

30/05/18 → 30/05/21

Project: Research

Physiology of oxygen transport in the mammalian kidney

Gardiner, B., Evans, R., Schroeder-Turk, G., Bertram, J. & Smith, D. W.

9/05/18 → 31/12/20

Project: Research

Translating colorectal cancer organoids into patient care

Abud, H., Worthley, D., Burgess, A., McMurrick, P., Firestein, R., Gibbs, P., Clevers, H., Price, T., Padbury, R. & Hewett, P.

Cancer Australia

16/04/18 → 15/04/21

Project: Research

Defining the epigenetic origins of maternally inherited disease.

Western, P., Gardner, D., Voss, A. K., van den Buuse, M., Adelson, D. L., Sims, N., Hutt, K., Dickinson, H., Stringer, J., Hill, R. & Gibson, W.

1/01/18 → 31/12/20

Project: Research

Tapping the power of pluripotency: The role of HMGA1 protein in stem cell renewal and cell fate transitions.

Anko, M., Kaslin, J., Davidovich, C. & Ramialison, M.

1/01/18 → 31/12/20

Project: Research

3D Cryo Correlative Light and Electron Microscopy Facility

Ramm, G., Kile, B., Lithgow, T., O'Bryan, M. & Naderer, T.

1/01/18 → 31/12/19

Project: Other

Codon bias: a hidden layer of translational regulation by estrogens

Furic, L., Larsson, O. & Topisirovic, I.

1/01/18 → 31/12/20

Project: Research

Novel targeting of therapy-resistant prostate cancer cells.

Taylor, R., Risbridger, G., Azad, A. & Nim, H.

1/01/18 → 31/12/20

Project: Research