Histology Platform

Projects

Host cell death signaling and susceptibility to bacterial gut infection

Project: Research

Novel targeting of the glucagon family of G protein coupled receptors

Project: Research

Engineering the second generation of growth factors and cytokines for regenerative medicine applications

Project: Research

Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-B activity

Project: Research

Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function

Project: Research

Reappraisal of the mechanisms underlying implantation success or failure

Project: Research

Targeting key regulators of innate immunity in inflammation-associated cancer

Project: Research

Mechanisms underlying the efficacy of bariatric surgery – insights from rat models of sleeve gastrectomy and the adjustable gastric band

Project: Research

Unveiling the human reprogramming pathway

Project: Research

Mild traumatic brain injuries and neurodegenerative disease

Project: Research

Codon bias: a hidden layer of translational regulation by estrogens

Project: Research

Targeting Survival programs in Acute Lymphoblastic Leukemia

Project: Research

Efficacy of Smac Mimetics and the role of FOXL2 in Ovarian Cancer

Project: Research

Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury

Project: Research

Does antenatal lactoferrin promote connectivity of the growth restricted brain?

Project: Research

Translating colorectal cancer organoids into patient care

Project: Research

Diagnosis and intervention for suboptimal brain development in low birthweight infants to prevent long-term motor, cognitive and behavioural problems

Project: Research

Understanding the roles of the EMT transcription factors in epigenetic remodelling and myeloid cell transformation.

Project: Research

Menkes disease research

Project: Research

Early life inflammation and development of cardiovascular disease

Project: Research

Modulating diet and the immune system to treat diabetic retinopathy

Project: Research

Novel signalling pathways leading to the activation of glomerular parietal epithelial cells

Project: Research

New and improved treatment strategies for neonatal seizures

Project: Research

Using reprogramming to generate late onset Alzheimer's disease microglia

Project: Research

Multiplex Active Ration Test for the Detection of Early Stage Ovarian Cancer

Project: Research

Imaging toxoplasmosis in the eye using genetically modified parasites and host mice

Project: Research

Boosting the immune system to treat diabetic retinopathy

Project: Research

Targeting the C5a-C5aR1 signalling axis in type 1 diabetic kidney disease

Project: Research

Targeting Prevention and Treatment of Hypertensive Cardiovascular Disease

Project: Research

Regulation of phosphoinositide 3-phosphate tumour suppressor activity

Project: Research

A neuro-immune axis regulates beige adipocyte development and function

Project: Research

A novel translational pipeline for the introduction of new immune-based therapies targeting localised and metastatic pancreatic ductal adenocarcinom

Project: Research

Creatine and Pregnancy Outcomes

Project: Research

Targeting MYC driven PC by combining targeted radionuclide therapy with ribosome biogenesis inhibition as a new therapy in CRPC and neuroendocrine PC

Project: Research

Targeting endosomal NOX2 oxidase in viral disease

Project: Research

Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.

Project: Research

Investigating pathways of mitochondrial quality control in diabetic kidney disease

Project: Research

Improving the lives of people at increased risk of cancer

Project: Research

Defining the Protective Role of the Innate Immune Molecule, NLRC5, in Stomach B-cell Lymphomagenesis

Project: Research

Unravelling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1

Project: Research

A novel strategy for targeting castrate-resistant prostate cancer

Project: Research

An in situ structural study of Drosophila embryonic patterning

Project: Research

Amniotic Exosomes - Nanomedicine for Bronchopulmonary Dysplasia

Project: Research

Mechanisms of manchette function.

Project: Research

A novel drug treatment that can potentially be used in all types of strokes and be given at emergency point of care

Project: Research

Curing blood cancers: rapid translation from target to drug to clinic

Project: Research

Understanding leukocyte function in inflammatory disease

Project: Research

Elucidating a new mechanism of endometrial receptivity establishment in women and its clinical significance

Project: Research

Promoting intestinal stem-cell mediated regeneration following damage: a critical role for Neuregulin 1

Project: Research

Diagnosis of Wolbachia and Dengue viruses in mosquitoes using vibrational spectroscopy

Project: Research

Improving breathing of preterm newborns exposed to inflammation during pregnancy

Project: Research

Imaging the HIV reservoir in vivo

Project: Research

Targeting the IL-1β inflammatory pathway for preventing preterm brain injury

Project: Research

Using reprogramming to generate Alzheimer's disease microglia

Project: Research

Evaluating novel therapeutics for chronic obstructive pulmonary disease

Project: Research

Understanding immune disorders of the gut

Project: Research

Finding the missing katanin required for male fertility

Project: Research

G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities

Project: Research

Using patient-derived organoids to guide the nonsurgical “watch and wait” approach for rectal cancer

Project: Research

Towards novel treatments for the cognitive impairments associated with schizophrenia

Project: Research

A new universal mechanism controlling body proportions in animals

Project: Research

Role of intrarenal nerves in the progression of hypertension and diabetic nephropathy

Project: Research

Manipulating the fine-tuning of the innate immune response in disease

Project: Research

Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function

Project: Research

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Project: Research

High dose testosterone: Enough rope for prostate cancer cells

Project: Research

Finding the holy grail; "off the shelf" neural stem cell therapy for perinatal stroke

Project: Research

Physiology of oxygen transport in the mammalian kidney

Project: Research

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Project: Research

Defining the epigenetic origins of maternally inherited disease.

Project: Research

Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy

Project: Research

Creatine Supplementation in Pregnancy: Utilising Cells' 'Built-In' Energy Buffering System

Project: Research

A new promise for the treatment of neonatal seizures.

Project: Research

Mechanism of action of a novel multifunctional bacterial secretion system

Project: Research

Molecular Genetics of Human Sexual Differentiation

Project: Research

Endosomal reactive oxygen species in tumour angiogenesis

Project: Research

Anti-sporulation strategies for Clostridium difficile infections

Project: Research

Protecting diabetic organs using a dual-acting compound delivered via injectable hydrogel

Project: Research

Understanding adolescent neurodevelopment: relevence to schizophrenia

Project: Other

Degradable nanocapsules for thromboprophylaxis and treatment of acute thrombosis

Project: Research

International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Project: Research

Central neural circuits subserving nutrient–activated thermogenesis - the basis of post prandial energy expenditure

Project: Research

Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

Project: Research

Ghrelin receptor signaling in the brain links hunger to mood and motivation

Project: Research

Precision Medicine for Prostate and Breast Cancer

Project: Research

Human embryo's secret weapon for implantation

Project: Research

Implementing neuroprotective strategies for fetal growth restriction

Project: Research

Reprogramming of adult cells for regenerative medicine therapies

Project: Research

Comparing and combining the therapeutic effects of Cynata MSCs with a clinically-used corticosteroid in a murine model of chronic allergic airways disease

Project: Research

Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring

Project: Research

Characterisation of PI3-kinase-dependent signalling networks in breast cancer

Project: Research

Tools fo Rebuilding Patient Tumours in the Laboratory

Project: Research

Boosting the immune system to treat diabetic retinopathy

Project: Research

JDRF Career Development Award - Mapping the mitochondrial signature of individuals with type 1 diabetes and nephropathy

Project: Research

Specific targeting of the TACE protease as a therapeutic strategy in lung adenocarcinoma and associated cachexia

Project: Research

Targeting the inflammasome; the key to curing Cerebral Palsy?

Project: Research

Novel treatments of fibrosis for hypertensive heart disease

Project: Research

Regulation of immune responses in the adult testis and male reproductive health

Project: Research

Examining the importance of DNA damage repair for oocyte quality, female fertility and offspring health

Project: Research

The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

Project: Research

Unveiling the epigenome dynamics through the pluripotency continuum

Project: Research

Combining cell and gene therapy to develop safe and more effective designer cell-based medicine for treating MS

Project: Research

The Meydan Family Foundation Diabetes Complications Research Hub

Project: Research

Smart Targeted Nanoparticles for Diagnosis and Therapy

Project: Research

Comparing different routes of Cynata-MSC administration in a murine model of chronic allergic airways disease

Project: Research

Novel role of innate immune DNA sensors in promoting gastric cancer

Project: Research

The role of NADPH oxidase-Nox5 in diabetic kidney disease: in vitro and in vivo studies

Project: Research

A New Anti-Diabetes Drug as a Novel Therapy for Ovarian Cancer

Project: Research

FPR2 is a therapeutic target in lung cancer

Project: Research

Mediator kinase as a therapeutic target for Wnt/B-catenin dependent malignancies

Project: Research

Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases

Project: Research

Interferon epsilon, a key cytokine in the pathophysiology of the female reproductive tract mucosa

Project: Research

Neural sensing of hunger links homeostatic and reward pathways

Project: Research

Chararacterisation of Topical Delivery System for Follistatin Treatment of Fibrotic Skin Diseases

Project: Research

Hunger-sensitive neural pathways influence appetite and behaviour

Project: Research

Molecular imaging and therapy of cardiac fibrosis in atrial fibrillation and heart failure

Project: Research

Effects of amniotic fluid ureaplasma infection, and its treatment, on brain development and

Project: Research

Therapeutic targeting of the colorectal epigenome

Project: Research

Evaluation of the biological effects of hydroxytyrosol; cancer and the Warburg effect

Project: Research

Defining the central role of podocyte depletion in the development, progression and management of glomerular disease

Project: Research

Research Output

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

Research output: Contribution to journal › Article › Research › peer-review

Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms

Research output: Contribution to journal › Article › Research › peer-review

Invariant natural killer T cells shape the gut microbiota and regulate neutrophil recruitment and function during intestinal inflammation

Research output: Contribution to journal › Article › Research › peer-review

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

Research output: Contribution to journal › Article › Research › peer-review

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

Research output: Contribution to journal › Article › Research › peer-review

Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Research output: Contribution to journal › Article › Research › peer-review

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

Research output: Contribution to journal › Article › Research › peer-review

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

Research output: Contribution to journal › Article › Research › peer-review

Tailored emulsion-templated porous polymer scaffolds for iPSC-derived human neural precursor cell culture

Research output: Contribution to journal › Article › Research › peer-review

The proliferative phase underpins endometrial development: Altered cytokine profiles in uterine lavage fluid of women with idiopathic infertility

Research output: Contribution to journal › Article › Research › peer-review

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Research output: Contribution to journal › Article › Research › peer-review

A novel Foxn1^eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

Research output: Contribution to journal › Article › Research › peer-review

Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli

Research output: Contribution to journal › Article › Research › peer-review

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

Research output: Contribution to journal › Article › Research › peer-review

Neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: comparison of young adult and geriatric marmoset monkeys

Research output: Contribution to journal › Article › Research › peer-review

RABL2 is required for hepatic fatty acid homeostasis and its dysfunction leads to steatosis and a diabetes-like state

Research output: Contribution to journal › Article › Research › peer-review

Examination of the ovotoxicity of 5-fluorouracil in mice

Research output: Contribution to journal › Article › Research › peer-review

Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

Research output: Contribution to journal › Article › Research › peer-review

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

Research output: Contribution to journal › Article › Research › peer-review

Mutations in the Katnb1 gene cause left-right asymmetry and heart defects

Research output: Contribution to journal › Article › Research › peer-review

Maternal low protein diet programmes low ovarian reserve in offspring

Research output: Contribution to journal › Article › Research › peer-review

Effects of intrauterine inflammation on cortical gray matter of near-term lambs

Research output: Contribution to journal › Article › Research › peer-review

Bioceramic nanocomposite thiol-acrylate polyHIPE scaffolds for enhanced osteoblastic cell culture in 3D

Research output: Contribution to journal › Article › Research › peer-review

Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Research output: Contribution to journal › Article › Research › peer-review

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

Research output: Contribution to journal › Article › Research › peer-review

Sex Reversal and Comparative Data Undermine the W Chromosome and Support Z-linked DMRT1 as the Regulator of Gonadal Sex Differentiation in Birds

Research output: Contribution to journal › Article › Research › peer-review

Optimizing the Dose of Erythropoietin Required to Prevent Acute Ventilation-Induced Cerebral White Matter Injury in Preterm Lambs

Research output: Contribution to journal › Article › Research › peer-review

Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart

Research output: Contribution to journal › Article › Research › peer-review

miR-222 isoforms are differentially regulated by type-I interferon

Research output: Contribution to journal › Article › Research › peer-review

Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation

Research output: Contribution to journal › Article › Research › peer-review

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Research output: Contribution to journal › Article › Research › peer-review

Chronic recurrent dehydration associated with periodic water intake exacerbates hypertension and promotes renal damage in male spontaneously hypertensive rats

Research output: Contribution to journal › Article › Research › peer-review

The ghrelin/GOAT system regulates obesity-induced inflammation in male mice

Research output: Contribution to journal › Article › Research › peer-review

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Research output: Contribution to journal › Article › Research › peer-review

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Research output: Contribution to journal › Article › Research › peer-review

Human podocyte depletion in association with older age and hypertension

Research output: Contribution to journal › Article › Research › peer-review

Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring

Research output: Contribution to journal › Article › Research › peer-review

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age

Research output: Contribution to journal › Article › Research › peer-review

BJD Research Letter: A profile of lipid dysregulation in Harlequin Ichthyosis

Research output: Contribution to journal › Letter › Research › peer-review

Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models

Research output: Contribution to journal › Article › Research › peer-review