Genome Modification Platform

Research output

Research output per year 2016 2016 2017 2018 2020 2022 2023 2023

• 28 Article

Research output per year

Research output per year

Search results

• 2023

  Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer’s disease

  Zhou, Y., Xie, L., Schröder, J., Schuster, I. S., Nakai, M., Sun, G., Sun, Y. B. Y., Mariño, E., Degli-Esposti, M. A., Marques, F. Z., Grubman, A., Polo, J. M. & Mackay, C. R., 13 Sept 2023, In: The Journal of Neuroscience. 43, 37, p. 6460-6475 59 p.

  Research output: Contribution to journal › Article › Research › peer-review
  10 Citations (Scopus)

• Gpr88 Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine

  Spark, D. L., Vermeulen, M. H., de la Fuente Gonzalez, R. A., Hatzipantelis, C. J., Rueda, P., Sepehrizadeh, T., De Veer, M., Mannoury la Cour, C., Fornito, A., Langiu, M., Stewart, G. D., Nithianantharajah, J. & Langmead, C. J., Oct 2023, In: Biological Psychiatry: Global Open Science. 3, 4, p. 1053-1061 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

• The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility

  Dunleavy, J. E. M., Graffeo, M., Wozniak, K., O'Connor, A. E., Merriner, D. J., Nguyen, J., Schittenhelm, R. B., Houston, B. J. & O'Bryan, M. K., Nov 2023, In: Development. 150, 22, 17 p., dev201956.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  1 Citation (Scopus)

• Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

  Hegron, A., Peach, C. J., Tonello, R., Seemann, P., Teng, S., Latorre, R., Huebner, H., Weikert, D., Rientjes, J., Veldhuis, N. A., Poole, D. P., Jensen, D. D., Thomsen, A. R. B., Schmidt, B. L., Imlach, W. L., Gmeiner, P. & Bunnett, N. W., 30 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, 12 p., e2220979120.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  8 Citations (Scopus)
• 2022

  Interferons limit autoantigen-specific CD8⁺ T-cell expansion in the non-obese diabetic mouse

  Jhala, G., Krishnamurthy, B., Brodnicki, T. C., Ge, T., Akazawa, S., Selck, C., Trivedi, P. M., Pappas, E. G., Mackin, L., Principe, N., Brémaud, E., De George, D. J., Boon, L., Smyth, I., Chee, J., Kay, T. W. H. & Thomas, H. E., 26 Apr 2022, In: Cell Reports. 39, 4, 21 p., 110747.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

  Chang, Y-C., Manent, J., Schroeder, J., Wong, S. F. L., Hauswirth, G. M., Shylo, N. A., Moore, E. L., Achilleos, A., Garside, V., Polo, J. M., Trainor, P. & McGlinn, E., Dec 2022, In: Nature Communications. 13, 1, 19 p., 7766.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  9 Citations (Scopus)

• UL49 is an essential subunit of the viral pre-initiation complex that regulates human cytomegalovirus gene transcription

  Turner, D. L., Fritzlar, S., Sadeghipour, S., Barugahare, A. A., Russ, B. E., Turner, S. J. & Mathias, R. A., 21 Oct 2022, In: iScience. 25, 10, 17 p., 105168.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  2 Citations (Scopus)
• 2020

  Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

  Howson, L. J., Awad, W., von Borstel, A., Lim, H. J., McWilliam, H. E. G., Sandoval-Romero, M. L., Majumdar, S., Hamzeh, A. R., Andrews, T. D., McDermott, D. H., Murphy, P. M., Le Nours, J., Mak, J. Y. W., Liu, L., Fairlie, D. P., McCluskey, J., Villadangos, J. A., Cook, M. C., Turner, S. J., Davey, M. S., & 2 othersOjaimi, S. & Rossjohn, J., 24 Jul 2020, In: Science Immunology. 5, 49, 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  50 Citations (Scopus)

• CRISP3 expression drives prostate cancer invasion and progression

  Volpert, M., Furic, L., Hu, J., O'Connor, A. E., Rebello, R. J., Keerthikumar, S., Evans, J., Merriner, D. J., Pedersen, J., Risbridger, G. P., McIntyre, P. & O'Bryan, M. K., Jul 2020, In: Endocrine-Related Cancer. 27, 7, p. 415-430 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• Effect of Ataluren on dystrophin mutations

  Berger, J., Li, M., Berger, S., Meilak, M., Rientjes, J. & Currie, P. D., Jun 2020, In: Journal of Cellular and Molecular Medicine. 24, 12, p. 6680-6689 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  25 Citations (Scopus)

• Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

  Carpinelli, M. R., De Vries, M. E., Auden, A., Butt, T., Deng, Z., Partridge, D. D., Miles, L. B., Georgy, S. R., Haigh, J. J., Darido, C., Brabletz, S., Brabletz, T., Stemmler, M. P., Dworkin, S. & Jane, S. M., 1 Mar 2020, In: Disease Models & Mechanisms. 13, 3, 14 p., dmm042218.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  21 Citations (Scopus)

• Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue

  Chonwerawong, M., Ferrand, J., Chaudhry, H. M., Higgins, C., Tran, L. S., Lim, S. S., Walker, M. M., Bhathal, P. S., Dev, A., Moore, G. T., Sievert, W., Jenkins, B. J., D'Elios, M. M., Philpott, D. J., Kufer, T. A. & Ferrero, R. L., Jul 2020, In: Gastroenterology. 159, 1, p. 169-182 22 p.

  Research output: Contribution to journal › Article › Research › peer-review
  19 Citations (Scopus)

• Topographical and Morphological Differences of Corneal Dendritic Cells during Steady State and Inflammation

  Jiao, H., Naranjo Golborne, C., Dando, S. J., McMenamin, P. G., Downie, L. E. & Chinnery, H. R., 17 Aug 2020, In: Ocular Immunology and Inflammation. 28, 6, p. 898-907 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  22 Citations (Scopus)
• 2019

  A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization

  Coughlan, E., Garside, V. C., Wong, S. F. L., Liang, H., Kraus, D., Karmakar, K., Maheshwari, U., Rijli, F. M., Bourne, J. & McGlinn, E., 19 Nov 2019, In: Cell Reports. 29, 8, p. 2408-2421 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

• Nod-like receptors are critical for gut–brain axis signalling in mice

  Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres-Fuentes, C., Goldfild, L. R., Gillis, S. E., Brust-Mascher, I., Rabasa, G., Wong, K. A., Lebrilla, C., Byndloss, M. X., Maisonneuve, C., Bäumler, A. J., Philpott, D. J., Ferrero, R. L., Barrett, K. E., & 2 othersReardon, C. & Gareau, M. G., 15 Dec 2019, In: The Journal of Physiology. 597, 24, p. 5777-5797 21 p.

  Research output: Contribution to journal › Article › Research › peer-review
  47 Citations (Scopus)
• 2018

  Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line

  Stephenson, S. E. M., Aumann, T. D., Taylor, J. M., Riseley, J. R., Li, R., Mann, J. R., Tomas, D. & Lockhart, P. J., 14 May 2018, In: Scientific Reports. 8, 1, 11 p., 7528.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

• Identification of dynamic undifferentiated cell states within the male germline

  La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In: Nature Communications. 9, 1, 18 p., 2819.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  64 Citations (Scopus)

• Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes

  Yap, J. Y., Wirasinha, R. C., Chan, A., Howard, D. R., Goodnow, C. C. & Daley, S. R., 1 Jul 2018, In: Immunology. 154, 3, p. 522-532 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)
• 2017

  A novel Foxn1^eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

  Barsanti, M., Lim, J. M. C., Hun, M. L., Lister, N., Wong, K., Hammett, M. V., Lepletier, A., Boyd, R. L., Giudice, A. & Chidgey, A. P., Feb 2017, In: European Journal of Immunology. 47, 2, p. 291-304 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  23 Citations (Scopus)

• Evidence that central pathways that mediate defecation utilize ghrelin receptors but do not require endogenous ghrelin

  Pustovit, R. V., Callaghan, B., Ringuet, M. T., Kerr, N. F., Hunne, B., Smyth, I. M., Pietra, C. & Furness, J. B., 1 Aug 2017, In: Physiological Reports. 5, 15, 11 p., e13385.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

• IL-2 prevents deletion of developing T-regulatory cells in the thymus

  Hu, D. Y., Wirasinha, R. C., Goodnow, C. C. & Daley, S. R., Jun 2017, In: Cell Death and Differentiation. 24, 6, p. 1007-1016 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  13 Citations (Scopus)

• INPP5E regulates phosphoinositide-dependent cilia transition zone function

  Dyson, J. M., Conduit, S. E., Feeney, S. J., Hakim, S., DiTommaso, T., Fulcher, A. J., Sriratana, A., Ramm, G., Horan, K. A., Gurung, R., Wicking, C., Smyth, I. & Mitchell, C. A., 2 Jan 2017, In: Journal of Cell Biology. 216, 1, p. 247-263 17 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  92 Citations (Scopus)

• New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

  O'Brien, C. M., Chy, H. S., Zhou, Q., Blumenfeld, S., Lambshead, J. W., Liu, X., Kie, J., Capaldo, B. D., Chung, T-L., Adams, T. E., Phan, T., Bentley, J. D., McKinstry, W. J., Oliva, K., McMurrick, P. J., Wang, Y-C., Rossello, F. J., Lindeman, G. J., Chen, D., Jarde, T., & 7 othersClark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L., 1 Mar 2017, In: Stem Cells. 35, 3, p. 626-640 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

• Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

  Furtado, M. B., Wilmanns, J. C., Chandran, A., Perera, J., Hon, O., Biben, C., Willow, T. J., Nim, H. T., Kaur, G., Simonds, S., Wu, Q., Willians, D., Salimova, E., Plachta, N., Denegre, J. M., Murray, S. A., Fatkin, D., Cowley, M., Pearson, J. T., Kaye, D., & 4 othersRamialison, M., Harvey, R. P., Rosenthal, N. A. & Costa, M. W., 23 Mar 2017, In: JCI Insight. 2, 6, p. e88271 18 p., e88271.

  Research output: Contribution to journal › Article › Research
  21 Citations (Scopus)
• 2016

  Brinp1^-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

  Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In: Molecular Autism. 7, 22, 20 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  33 Citations (Scopus)

• Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

  Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In: Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

• Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

  Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In: Biology Open. 6, 11, 12 p., 160098.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

• RABL2 is required for hepatic fatty acid homeostasis and its dysfunction leads to steatosis and a diabetes-like state

  Lo, J. C. Y., O'Connor, A. E., Andrews, Z. B., Lo, C., Tiganis, T., Watt, M. J. & O'Bryan, M. K., Dec 2016, In: Endocrinology. 157, 12, p. 4732-4743 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  14 Citations (Scopus)