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Projects

International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Project: Research

Evaluation of the biological effects of hydroxytyrosol; cancer and the Warburg effect

Project: Research

Novel immune cell subsets in the CNS and supporting tissues

Project: Research

Nuclear transport in stress

Project: Research

A novel molecular mechanism controlling myelopoiesis

Project: Research

Endosomal reactive oxygen species in tumour angiogenesis

Project: Research

The Hippo Pathway And Melanoma Growth

Project: Research

Phase 1 clinical trial of amnion cell therapy for stroke

Project: Research

Protecting diabetic organs using a dual-acting compound delivered via injectable hydrogel

Project: Research

Degradable nanocapsules for thromboprophylaxis and treatment of acute thrombosis

Project: Research

Tools fo Rebuilding Patient Tumours in the Laboratory

Project: Research

Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

Project: Research

Understanding marine life-history patterns: an eco-energetics approach

Project: Research

A Novel Combination Treatment for Ovarian Granulosa Cell Tumors

Project: Research

Development of a Microfluidic Blood Platelet Analyser

Project: Research

A New Anti-Diabetes Drug as a Novel Therapy for Ovarian Cancer

Project: Research

Reprogramming of adult cells for regenerative medicine therapies

Project: Research

Transforming the treatment landscape in elderly Acute Myeloid Leukaemia (AML)

Project: Research

New strategies to improve personalized immunotherapy of breast cancer

Project: Other

Developing new therapeutic strategies for brain cancer

Project: Research

Understanding the complexity of antigen presentation

Project: Research

Promoting intestinal stem-cell mediated regeneration following damage: a critical role for Neuregulin 1

Project: Research

Conventional and unconventional T cells in interstitial kidney disease

Project: Research

Using reprogramming to generate Alzheimer's disease microglia

Project: Research

Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring

Project: Research

Immunospheres: Creating an immune system in a microparticle

Project: Research

Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interaction between polymyxins and bacterial membranes

Project: Research

Understanding immune disorders of the gut

Project: Research

Finerenone in diabetic retinopathy

Project: Research

Combining cell and gene therapy to develop safe and more effective designer cell-based medicine for treating MS

Project: Research

Improving survival in myelofibrosis

Project: Research

To test the effects of XPro1595 on the cellular immune profile in a phase I study for InmuneBio

Project: Research

The regulatory role of Clec12A in antigen presentation and inflammatory disease

Project: Research

Defining role of inflammatory signals in enhancing motoneuron regeneration

Project: Research

Dying stem cells as a mechanism in mesenchymal stromal cell therapy

Project: Research

Develoment of small molecules for neuroprotection and repair during progressive MS

Project: Research

Using reprogramming to generate late onset Alzheimer's disease microglia

Project: Research

Muscle fusion as a delivery mechanism to repair ailing muscles from heritable muscle diseases

Project: Research

Unconventional mechanisms for activating the NLRP3 inflammasome

Project: Research

Does boosting the adaptive immune system reduce hypertensive diabetic retinopathy?

Project: Research

Diversification of immune responses through unanticipated proteolytic mechanisms

Project: Research

Stem cell based strategies for re-establishing T cell immunity in aging and disease.

Project: Research

The role of Il21 in B-cell activation

Project: Research

Improving the safety and predictable efficacy of thrombolytic therapy in acute ischaemic stroke

Project: Research

Interferon epsilon, a key cytokine in the pathophysiology of the female reproductive tract mucosa

Project: Research

Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases

Project: Research

Design and engineering of adnectins for diagnosis and therapy

Project: Research

Targeting Prevention and Treatment of Hypertensive Cardiovascular Disease

Project: Research

Mechanisms of mesenchymal stem cell therapy

Project: Research

Regulatory networks defining stem cell populations in the adult male germline

Project: Research

Molecular imaging and therapy of cardiac fibrosis in atrial fibrillation and heart failure

Project: Research

Unveiling the epigenome dynamics through the pluripotency continuum

Project: Research

Unveiling the human reprogramming pathway

Project: Research

High blood pressure and gut microbiota: mechanisms and therapeutic potential

Project: Research

Multiple sclerosis research in the Merson Group (ARMI)

Project: Research

Smart Targeted Nanoparticles for Diagnosis and Therapy

Project: Research

Does the amount of PAR4 on the platelet surface regulate thrombosis?

Project: Research

Understanding the roles of the EMT transcription factors in epigenetic remodelling and myeloid cell transformation.

Project: Research

Development of small molecules for neuroprotection and repair during progressive multiple sclerosis

Project: Research

INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE

Project: Research

Decoding mechanisms of brain-intestinal communication

Project: Research

Targeting oxidant-dependent pathways to improve stroke outcomes in COPD

Project: Research

Protecting against malaria through liver-resident memory T cells

Project: Research

Targeted therapies for chemo-resistant leukaemia cells

Project: Research

Identifying the function of nucleic acid binding by the PRC2 accessory protein JARID2.

Project: Research

Cells and nanobiomaterials to treat and prevent Pelvic Organ Prolapse

Project: Research

Treatments for glomerulonephritis that harness antigen specific regulatory cells

Project: Research

Regulation of immune responses in the adult testis and male reproductive health

Project: Research

Rotea Formulation, Fill and Fnish

Project: Research

Immunospheres: creating an immune system in a microparticle

Project: Research

Development of a Novel SLE therapeutic

Project: Research

Systems approaches to understanding the assembly of mitochondrial machines

Project: Research

Efficacy of Smac Mimetics and the role of FOXL2 in Ovarian Cancer

Project: Research

Alzheimers and Brain Repair research

Project: Research

Multiple paths of TFH differentiation and their impact on B cell protection against infection

Project: Research

Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing

Project: Research

Nox5 as a potential biomarker for cardiovascular disease including in diabetes

Project: Research

Identifying the source and nature of spliced and hybrid insulin peptides

Project: Research

The role of NOX4 in antioxidant defence and mitochondrial biogenesis in muscle

Project: Research

Immunomodulatory Mast Cells as Therapeutic Agents in Chronic Autoimmune and Acute Inflammatory Kidney Disease

Project: Research

Engineering the second generation of growth factors and cytokines for regenerative medicine applications

Project: Research

2018 Al & Val Rosentrauss Fellowship

Project: Research

Generation of human intestinal stem cells by direct reprogramming

Project: Research

The Meydan Family Foundation Diabetes Complications Research Hub

Project: Research

Improving on nature: diversifying glycopeptide antibiotics to kill the bacterial pathogen Staphylococcus aureus

Project: Research

Systems approaches to understanding mitochondrial function and dysfunction in disease

Project: Research

Viral targeting of STAT proteins: roles in disease

Project: Research

Targeting endosomal NOX2 oxidase in viral disease

Project: Research

ADAM metalloprotease inhibition for treatment of colorectal cancer

Project: Research

RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations

Project: Research

Next Generation Targeting of DNA-Methylation in Poor Risk Lymphoid Cancer

Project: Research

Tapping the power of pluripotency: The role of HMGA1 protein in stem cell renewal and cell fate transitions.

Project: Research

Amniotic Exosomes - Nanomedicine for Bronchopulmonary Dysplasia

Project: Research

Next generation targeting of DNA methylation to translate improved outcomes in T-cell lymphoma

Project: Research

Host cell death signaling and susceptibility to bacterial gut infection

Project: Research

Boosting the immune system to treat diabetic retinopathy

Project: Research

Dissecting the significance of pigment heterogeneity in cutaneous melanoma

Project: Research

The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

Project: Research

Identification of E-protein complexes controlling natural killer cell fate and tumour immunity

Project: Research

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Project: Research

Therapeutic targeting of CIMP+ Colorectal Cancers

Project: Research

Defining the epigenetic origins of maternally inherited disease.

Project: Research

Experimental co-evolution of Yeast and E. coli.

Project: Research

Activation and inhibition of the Plasminogen/Plasmin system

Project: Research

A Systems Approach to the Adaptive Immune Response

Project: Research

Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.

Project: Research

Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Project: Research

An in situ structural study of Drosophila embryonic patterning

Project: Research

Epigenetic regulation of humoral immune responses.

Project: Research

A new set of targets and drugs for improving stroke outcome

Project: Other

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Project: Research

Clec9A targeting antibodies as a new immunotherapy for prostate cancer

Project: Research

Regulatory architecture of the trunk-to-tail transition

Project: Research

A predictive computational framework for targeted reprogramming of castrate resistant prostate cancer

Project: Research

Understanding leukocyte function in inflammatory disease

Project: Research

Assessing and comparing function of brain organoids from persons with dementia and normal controls.

Project: Research

Single cell transcriptional profiling of effective flu-specific T cell immunity

Project: Research

Genetically engineering regulatory T cells to treat SLE

Project: Research

Characterising and inducing a protective microglia phenotype in human AD

Project: Other

Bacterial metabolite mediated regulation of the immune and metabolic systems

Project: Research

Defining key determinants of HLA mediated T cell tolerance and autoimmunity

Project: Research

Confocal and single molecule microscopes for Systems Microscopy

Project: Other

Defining the efficacy of blocking Serine phosphorylated STAT3 in the treatment of gastric cancer

Project: Research

G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities

Project: Research

PROTACs as a novel therapeutic strategy to enable colorectal cancer precision medicine

Project: Research

Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy

Project: Research

Targeting antigen to Clec9A on dendritic cell for humoral immunity

Project: Research

Translating colorectal cancer organoids into patient care

Project: Research

Manipulating the fine-tuning of the innate immune response in disease

Project: Research

Molecular Genetics of Human Sexual Differentiation

Project: Research

Long-term outcomes after paediatric traumatic brain injury

Project: Research

High dose testosterone: Enough rope for prostate cancer cells

Project: Research

Single-cell genomic interrogation of poor-risk Hodgkin lymphoma to annotate intraclonal heterogeneity and evolution at relapse

Project: Research

Investigation into epigenetic defects and new therapeutic strategy in ATRX mutated gliomas

Project: Research

Efficacy of Smac Mimetics to treat Epithelial Ovarian Cancer and Granulosa Cell tumours and The role of the FOXL2 C134W mutation in Granulosa Cell Tumours

Project: Research

Assembly and misassembly of mitochondrial respiratory chain Complex I

Project: Research

Novel strategies to improve stroke outcome

Project: Research

Research Output

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Research output: Contribution to journal › Article › Research › peer-review

Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Research output: Contribution to journal › Article › Research › peer-review

SCA-1 labels a subset of estrogen-responsive bipotential repopulating cells within the CD24⁺ CD49f^hi mammary stem cell-enriched compartment

Research output: Contribution to journal › Article › Research › peer-review

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Research output: Contribution to journal › Article › Research › peer-review

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

Research output: Contribution to journal › Article › Research › peer-review

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Research output: Contribution to journal › Article › Research › peer-review

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Research output: Contribution to journal › Article › Research › peer-review

Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation

Research output: Contribution to journal › Article › Research › peer-review

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Research output: Contribution to journal › Article › Research › peer-review

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

Research output: Contribution to journal › Article › Research › peer-review

The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4⁺ T-cells

Research output: Contribution to journal › Article › Research › peer-review

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Research output: Contribution to journal › Article › Research › peer-review

A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection

Research output: Contribution to journal › Article › Research › peer-review

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Research output: Contribution to journal › Article › Research › peer-review

Epitope-tagged yeast strains reveal promoter driven changes to 3'-end formation and convergent antisense-transcription from common 3' UTRs

Research output: Contribution to journal › Article › Research › peer-review

Identification of dynamic undifferentiated cell states within the male germline

Research output: Contribution to journal › Article › Research › peer-review

Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Research output: Contribution to journal › Article › Research › peer-review

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

Research output: Contribution to journal › Article › Research › peer-review

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

Research output: Contribution to journal › Article › Research › peer-review

Amnion epithelial cells promote lung repair via lipoxin A₄

Research output: Contribution to journal › Article › Research › peer-review

CXCR5⁺ follicular cytotoxic T cells control viral infection in B cell follicles

Research output: Contribution to journal › Article › Research › peer-review

Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein–Protein Interactions

Research output: Contribution to journal › Article › Research › peer-review

A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia

Research output: Contribution to journal › Article › Research › peer-review

Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation

Research output: Contribution to journal › Article › Research › peer-review

Serpinb9 is a marker of antigen cross-presenting dendritic cells

Research output: Contribution to journal › Article › Research › peer-review

miR-222 isoforms are differentially regulated by type-I interferon

Research output: Contribution to journal › Article › Research › peer-review

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling

Research output: Contribution to journal › Article › Research › peer-review

Cell Type of Origin Dictates the Route to Pluripotency

Research output: Contribution to journal › Article › Research › peer-review

Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells

Research output: Contribution to journal › Article › Research › peer-review

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

Research output: Contribution to journal › Article › Research › peer-review

Characterization of Tfrc-mutant mice with microcytic phenotypes

Research output: Contribution to journal › Article › Research › peer-review

Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges

Research output: Contribution to journal › Article › Research › peer-review

Age-Related Decline in Primary CD8⁺ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8⁺ T Cells

Research output: Contribution to journal › Article › Research › peer-review

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Research output: Contribution to journal › Article › Research › peer-review

WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Research output: Contribution to journal › Article › Research › peer-review

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C∗06: 02 molecule

Research output: Contribution to journal › Article › Research › peer-review

The ghrelin/GOAT system regulates obesity-induced inflammation in male mice

Research output: Contribution to journal › Article › Research › peer-review