Cryo-Electron Microscopy

Projects

An in situ structural study of Drosophila embryonic patterning

Project: Research

Phosphoinositide regulation of lysosome reformation during autophagy

Project: Other

Novel Babesia proteins and their roles in the pathogenesis of tick fever

Project: Research

Activation and inhibition of the Plasminogen/Plasmin system

Project: Research

Mechanism of action of a novel multifunctional bacterial secretion system

Project: Research

Molecular control of efficacy at glucagon family of receptors

Project: Research

3D Cryo Correlative Light and Electron Microscopy Facility

Project: Other

Microtubule structure in nervous system repair

Project: Research

Understanding leukocyte function in inflammatory disease

Project: Research

Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

Project: Research

Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical Efficacy

Project: Research

The role of neuronal activity in promoting remyelination of the brain

Project: Research

How do MACPF/CDC proteins punch giant holes in lipid membranes?

Project: Research

Defining role of inflammatory signals in enhancing motoneuron regeneration

Project: Research

Structural basis for ribosomal docking on a picornavirus type I IRES

Project: Research

Antigen presentation, recognition and the immune response

Project: Research

Assembly and Function of the Engines of Coagulation: The Prothrombinase and Intrinsic Xase Complexes

Project: Research

Characterising and inducing a protective microglia phenotype in human AD

Project: Research

Develoment of small molecules for neuroprotection and repair during progressive MS

Project: Research

Biosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues

Project: Research

Regulation of histone methylation by polycomb-like proteins

Project: Research

Pushing the Limits of Fluorescence Microscopy with Adaptive Optics

Project: Research

Smart Targeted Nanoparticles for Diagnosis and Therapy

Project: Research

Cells and nanobiomaterials to treat and prevent Pelvic Organ Prolapse

Project: Research

Novel genes in skeletal muscle disease

Project: Research

mtDNA release and novel applications for caspase inhibition

Project: Research

Confocal and single molecule microscopes for Systems Microscopy

Project: Other

Does regeneration of normal-appearing myelin improve functional recovery in a mouse model of multiple sclerosis?

Project: Research

Living on air: how do bacteria scavenge atmospheric trace gases?

Project: Research

Establishing the role of apoptosis and mtDNA in lupus pathobiology

Project: Research

Nature-inspired electrochemical conversion of nitrogen to ammonia

Project: Research

Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing

Project: Research

Novel targeting of the glucagon family of G protein coupled receptors

Project: Research

Evaluation of therapeutic approaches for FLNC myofibrillar myopathy

Project: Research

A structural understanding of calcitonin gene-related peptide and adrenomedullin function

Project: Research

Next-generation prostate cancer therapies based on precision nanomedicines

Project: Research

A structural understanding of class B G protein-coupled receptor function

Project: Research

Structural and functional characterisation of the oncogene P-Rex1

Project: Research

A neuro-immune axis regulates beige adipocyte development and function

Project: Research

PhD Project: Altered Vitamin D responsiveness in Multiple Sclerosis Immune Cells.

Project: Research

Scalable and tuneable vertically aligned silicon nanotube {VA-SiNT) arrays for parallel intracellular delivery and sampling

Project: Research

Prophylactic vaccine development for the elimination of Hepatitis C

Project: Research

Epigenetic programming by histone methyltransferase in the bone marrow hematopoietic stem cells contributes diabetic associated atherosclerosis

Project: Research

Understanding how mitochondrial repair pathways cooperate to maintain mitochondrial health

Project: Research

Structure-function of type I interferon receptors: informing the basis for selective modulation of signal transduction andfunction

Project: Research

Re-engineering of antibiotics informed by antimicrobial resistance mechanisms

Project: Research

Molecular mechanism for the regulation of Polycomb repressive complex 2

Project: Research

Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors

Project: Research

An integrative structural biology approach to understanding the SAGA transcriptional master regulator implicated in cancer and development

Project: Research

Nano-capsule technology and Green Chemical Processes

Project: Research

NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS

Project: Research

High resolution structural determination of pathogenic flaviviruses by cryo-EM using a chimeric platform

Project: Research

Understanding and Creating Instrument Generated Data Collections

Project: Research

The role of structure in the formation and properties of glasses.

Project: Research

Structural studies of a novel nematocidal protein from the edible fungus, Corprinopsis cinerea

Project: Research

Improving on nature: diversifying glycopeptide antibiotics to kill the bacterial pathogen Staphylococcus aureus

Project: Research

Molecular basis for stress-induced gene regulation - a model system to understand transcriptional deregulation in cancer and neurological disease

Project: Research

Translating membrane proteins into therapeutics; from bedside to bench

Project: Research

Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring

Project: Research

Elucidating the architecture of fibres formed by designed β-amino acid containing peptides

Project: Research

Develop RAFT emulsion polymerization process that fulfils the basic requirement of industrial products

Project: Research

NHMRC Research Fellowship

Project: Research

RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations

Project: Research

Degradable nanocapsules for thromboprophylaxis and treatment of acute thrombosis

Project: Research

Immunobiology and Immunotherapy of Cancer

Project: Research

Research Output

In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly

Research output: Contribution to journal › Article › Research › peer-review

Characterization of Key Bio-Nano Interactions between Organosilica Nanoparticles and Candida albicans

Research output: Contribution to journal › Article › Research › peer-review

Highly dispersed TiO₂nanocrystals and carbon dots on reduced graphene oxide: Ternary nanocomposites for acceleratedphotocatalytic water disinfection

Research output: Contribution to journal › Article › Research › peer-review

AgarFix: Simple and accessible stabilization of challenging single-particle cryo-EM specimens through crosslinking in a matrix of agar

Research output: Contribution to journal › Article › Research › peer-review

Delivery of femtolitre droplets using surface acoustic wave based atomisation for cryo-EM grid preparation

Research output: Contribution to journal › Article › Research › peer-review

Methods in renal research: Measurement of autophagic flux in the renal cortex ex vivo

Research output: Contribution to journal › Review Article › Other › peer-review

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Research output: Contribution to journal › Article › Research › peer-review

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

Research output: Contribution to journal › Review Article › Research › peer-review

Modified Organosilica Core-Shell Nanoparticles for Stable pH Sensing in Biological Solutions

Research output: Contribution to journal › Article › Research › peer-review

Self-assembled enzyme nanoparticles for carbon dioxide capture

Research output: Contribution to journal › Article › Research › peer-review

cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria

Research output: Contribution to journal › Article › Research › peer-review

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Research output: Contribution to journal › Article › Research › peer-review

Structure and function of the open canalicular system–the platelet’s specialized internal membrane network

Research output: Contribution to journal › Review Article › Research › peer-review

KBTBD13 is an Actin-Binding Protein that Modulates Muscle Kinetics. Journal of Clinical Investigation

Research output: Contribution to journal › Article › Research › peer-review

The middle fragment of Helicobacter pylori CagA induces Actin rearrangement and triggers its own uptake into gastric epithelial cells

Research output: Contribution to journal › Article › Research › peer-review

Structural characterization of Clostridium sordellii spores of diverse human, animal, and environmental origin and comparison to Clostridium difficile spores

Research output: Contribution to journal › Article › Research › peer-review

Constructing ultrathin film with "memory" photocatalytic activity from monolayered tungstate nanodots

Research output: Contribution to journal › Article › Research › peer-review

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Research output: Contribution to journal › Article › Research › peer-review

Plasmonic isomers via DNA-based self-assembly of gold nanoparticles

Research output: Contribution to journal › Article › Research › peer-review

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin

Research output: Contribution to journal › Article › Research › peer-review

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract

Research output: Contribution to journal › Article › Research › peer-review

Structure of the poly-C9 component of the complement membrane attack complex

Research output: Contribution to journal › Article › Research › peer-review

Blended Nanostructured Degradable Mesh with Endometrial Mesenchymal Stem Cells Promotes Tissue Integration and Anti-Inflammatory Response in Vivo for Pelvic Floor Application

Research output: Contribution to journal › Article › Research › peer-review

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Research output: Contribution to journal › Article › Research › peer-review

PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery

Research output: Contribution to journal › Article › Research › peer-review

Structure of the adenosine-bound human adenosine A₁ receptor-G_i complex

Research output: Contribution to journal › Article › Research › peer-review

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Research output: Contribution to journal › Article › Research › peer-review

Structure and membrane topography of the vibrio-type secretin complex from the type 2 secretion system of enteropathogenic Escherichia coli

Research output: Contribution to journal › Article › Research › peer-review

Cryo-EM structure of the active, G_s-protein complexed, human CGRP receptor

Research output: Contribution to journal › Article › Research › peer-review

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Research output: Contribution to journal › Article › Research › peer-review

Highly dispersed TiO₂ nanocrystals and WO₃ nanorods on reduced graphene oxide: Z-scheme photocatalysis system for accelerated photocatalytic water disinfection

Research output: Contribution to journal › Article › Research › peer-review

Limiting neuronal nogo receptor 1 signaling during experimental autoimmune encephalomyelitis preserves axonal transport and abrogates inflammatory demyelination

Research output: Contribution to journal › Article › Research › peer-review

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

Research output: Contribution to journal › Article › Research › peer-review

RGD inhibition of itgb1 ameliorates laminin-a2 deficient zebrafish fibre pathology

Research output: Contribution to journal › Article › Research › peer-review