Research output per year
Research output per year
Equipments Details
Description
The Centre for Drug Candidate Optimisation (CDCO) is a collaborative research centre based within the Monash Institute of Pharmaceutical Sciences that provides biopharmaceutical lead optimisation expertise to academic, commercial and not-for-profit drug discovery programs.
Drug candidate optimisation is a key component of modern drug discovery, playing a critical role in compound design, selection and progression. Optimising physicochemical, metabolism and pharmacokinetic properties of drug candidates is essential in guiding medicinal chemistry, developing formulation and delivery strategies, and informing dosing regimens to ensure safety and efficacy.
Drug candidate optimisation is a key component of modern drug discovery, playing a critical role in compound design, selection and progression. Optimising physicochemical, metabolism and pharmacokinetic properties of drug candidates is essential in guiding medicinal chemistry, developing formulation and delivery strategies, and informing dosing regimens to ensure safety and efficacy.
Research output
- 5 Article
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On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
Edgar, R. C. S., Malcolm, T. R., Siddiqui, G., Giannangelo, C., Counihan, N. A., Challis, M., Duffy, S., Chowdhury, M., Marfurt, J., Dans, M., Wirjanata, G., Noviyanti, R., Daware, K., Suraweera, C. D., Price, R. N., Wittlin, S., Avery, V. M., Drinkwater, N., Charman, S. A. & Creek, D. J. & 3 others, , 12 Jun 2024, In: mBio. 15, 6, 27 p., e0096624.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex
Choo, X. Y., McInnes, L. E., Grubman, A., Wasielewska, J. M., Belaya, I., Burrows, E., Quek, H., Martín, J. C., Loppi, S., Sorvari, A., Rait, D., Powell, A., Duncan, C., Liddell, J. R., Tanila, H., Polo, J. M., Malm, T., Kanninen, K. M., Donnelly, P. S. & White, A. R., 14 Sept 2022, In: International Journal of Molecular Sciences. 23, 18, 27 p., 10722.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Link opens in a new tab Citations (Scopus) -
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., Fidock, D. A., Shore, E. R., Roberts, N. L., Wong, M. H. L., Hong, W. D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo, F. J., Sanz, L., Rodrigues, J., Cortes, C. G. & Herreros, E. & 2 others, , 24 May 2017, In: Nature Communications. 8, 10 p., 15159.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile57 Link opens in a new tab Citations (Scopus)
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Development of Novel Small Molecules for Therapeutic Intervention in Pulmonary Arterial Hypertension (PAH)
Stockton, K. (Primary Chief Investigator (PCI)), Leach, K. (Chief Investigator (CI)), Stupple, P. (Chief Investigator (CI)), Bourke, J. (Chief Investigator (CI)), Mennen, G. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)) & Rahmani, R. (Partner Investigator (PI))
Department of Education (Australia), BioCurate Pty Ltd
19/03/26 → 18/03/27
Project: Research
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Fatty acid binding protein 5 at brain barriers: a contributor to motor neurone disease
Nicolazzo, J. (Primary Chief Investigator (PCI)), Oikari, L. (Chief Investigator (CI)), Rogers, M.-L. (Chief Investigator (CI)) & Keenan, R. (Chief Investigator (CI))
5/01/26 → 4/01/29
Project: Research
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Allosteric modulation of muscarinic receptors for the treatment of neurocognitive deficits
Christopoulos, A. (Primary Chief Investigator (PCI))
1/01/26 → 31/12/30
Project: Research