Research output per year
Research output per year
Equipments Details
Description
The Centre for Drug Candidate Optimisation (CDCO) is a collaborative research centre based within the Monash Institute of Pharmaceutical Sciences that provides biopharmaceutical lead optimisation expertise to academic, commercial and not-for-profit drug discovery programs.
Drug candidate optimisation is a key component of modern drug discovery, playing a critical role in compound design, selection and progression. Optimising physicochemical, metabolism and pharmacokinetic properties of drug candidates is essential in guiding medicinal chemistry, developing formulation and delivery strategies, and informing dosing regimens to ensure safety and efficacy.
Drug candidate optimisation is a key component of modern drug discovery, playing a critical role in compound design, selection and progression. Optimising physicochemical, metabolism and pharmacokinetic properties of drug candidates is essential in guiding medicinal chemistry, developing formulation and delivery strategies, and informing dosing regimens to ensure safety and efficacy.
Research output
- 4 Article
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Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex
Choo, X. Y., McInnes, L. E., Grubman, A., Wasielewska, J. M., Belaya, I., Burrows, E., Quek, H., Martín, J. C., Loppi, S., Sorvari, A., Rait, D., Powell, A., Duncan, C., Liddell, J. R., Tanila, H., Polo, J. M., Malm, T., Kanninen, K. M., Donnelly, P. S. & White, A. R., 14 Sep 2022, In: International Journal of Molecular Sciences. 23, 18, 27 p., 10722.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., Fidock, D. A., Shore, E. R., Roberts, N. L., Wong, M. H. L., Hong, W. D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo, F. J., Sanz, L., Rodrigues, J., Cortes, C. G., Herreros, E., & 2 others, 24 May 2017, In: Nature Communications. 8, 10 p., 15159.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile47 Citations (Scopus) -
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In: Nature Communications. 8, 13 p., 14232.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile92 Citations (Scopus)
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Collaborative Study Program Agreement with The University of Auckland (Wilson) for Lead Optimisation Studies
30/03/23 → 31/12/23
Project: Research
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Discovery of new metabolic functions in Plasmodium parasites
Australian Research Council (ARC)
1/01/23 → 31/12/26
Project: Research
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D., Valant, C., Carbone, S., Mobbs, J., Thal, D., Scammells, P., King, S. K., Imlach, W., Hamilton, J. A. & Veldhuis, N.
1/01/23 → 31/12/26
Project: Research