Bioinformatics Platform

Projects

Clinical implications of trans-kingdom microbial interactions in the transplanted lung

Project: Research

Epigenetic regulation of humoral immune responses.

Project: Research

Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases

Project: Research

An investigation into metabolic competition between host and pathogen in infection.

Project: Research

Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment (BONANZA) Trial

Project: Other

Viral hijacking of the nucleolar DNA-damage response machinery: novel mechanisms to regulate host cell biology

Project: Research

A Systems Approach to the Adaptive Immune Response

Project: Research

An integrated virtual cell approach towards elucidating the systems pharmacology of antibiotics against Pseudomonas aeruginosa

Project: Research

Single cell transcriptional profiling of effective flu-specific T cell immunity

Project: Research

Bacterial metabolite mediated regulation of the immune and metabolic systems

Project: Research

Control of host-pathogen interactions and fungal virulence by short chain fatty acids

Project: Research

Defining the central role of podocyte depletion in the development, progression and management of glomerular disease

Project: Research

Understanding leukocyte function in inflammatory disease

Project: Research

Assessing and comparing function of brain organoids from persons with dementia and normal controls.

Project: Research

Tapping the power of pluripotency: The role of HMGA1 protein in stem cell renewal and cell fate transitions.

Project: Research

Improving the lives of people at increased risk of cancer

Project: Research

Understanding how the Helicobacter pylori pilin protein CagL promotes gastric cancer

Project: Research

NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS

Project: Research

Bacterial and Host Drivers of Fulminant Community-acquired Acinetobacter baumannii Infection

Project: Research

Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

Project: Research

The Meydan Family Foundation Diabetes Complications Research Hub

Project: Research

From genomics to new treatments for myeloproliferative neoplasms

Project: Research

Next Generation Targeting of DNA-Methylation in Poor Risk Lymphoid Cancer

Project: Research

NIAID Centers of Excellence for Influenza Research and Surveillance

Project: Research

Investigating Pathways of Lipoglycan Formation in the Bacterial Cell Wall

Project: Research

Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment (BONANZA) Trial

Project: Research

Nuclear transport in stress

Project: Research

Identification of molecular signatures in Indigenous Australians with systemic lupus erythematosus.

Project: Research

A neuro-immune axis regulates beige adipocyte development and function

Project: Research

Re-engineering of antibiotics informed by antimicrobial resistance mechanisms

Project: Research

Identifying Novel Molecular Targets for Treating Chronic Pain.

Project: Research

Improving Global Tuberculosis Control with the "AuTuMN" Platform

Project: Research

Novel immune cell subsets in the CNS and supporting tissues

Project: Research

Elucidating a novel mechanism for coping with harmful mutations

Project: Research

Evaluation of the biological effects of hydroxytyrosol; cancer and the Warburg effect

Project: Research

Amniotic Exosomes - Nanomedicine for Bronchopulmonary Dysplasia

Project: Research

Hacking the genome for junk DNA to tackle childhood heart disease

Project: Research

Pushing the Limits of Fluorescence Microscopy with Adaptive Optics

Project: Research

Novel role of innate immune DNA sensors in promoting gastric cancer

Project: Research

A therapy to restore ageing defects in egg and sperm

Project: Research

The Hippo signalling pathway in dividing and non-dividing cells

Project: Research

Unveiling the human reprogramming pathway

Project: Research

Exploratory analysis of circulating-free RNA as a non-invasive biomarker in multiple myeloma utilising the Myeloma and Related Diseases Registry (MRDR) and the Australasian Myeloma Research consortium (AMARC)

Project: Research

Global regulatory networks that control virulence in Clostridium perfringens

Project: Research

Enhancing anti-parasitic drug discovery with metabolomics

Project: Research

The PRECISE assay: Personalised medicine for cancer patients using next-generation sequencing

Project: Research

High blood pressure and gut microbiota: mechanisms and therapeutic potential

Project: Research

International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Project: Research

Unveiling the epigenome dynamics through the pluripotency continuum

Project: Research

Targeted therapies for chemo-resistant leukaemia cells

Project: Research

Multiple sclerosis research in the Merson Group (ARMI)

Project: Research

Development of a novel bacteriophage treatment regime to combat and re-sensitise multiply antibiotic resistant Acinetobacter baumannii infections

Project: Research

Next Generation of bespoke treatments: Artificial intelligence aiding in prognoses in treatment plans

Project: Research

Frailty stratified, randomised controlled Bayesian adaptive trial of bortezomib versus lenalidomide in transplant-ineligible myeloma – the FRAIL-M study

Project: Research

Defining the Protective Role of the Innate Immune Molecule, NLRC5, in Stomach B-cell Lymphomagenesis

Project: Research

Interferon epsilon, a key cytokine in the pathophysiology of the female reproductive tract mucosa

Project: Research

Early detection of primary aldosteronism, an under-diagnosed but frequently curable cause of hypertension

Project: Research

Mechanism of action of a novel multifunctional bacterial secretion system

Project: Research

Novel Babesia proteins and their roles in the pathogenesis of tick fever

Project: Research

Stem cell based strategies for re-establishing T cell immunity in aging and disease.

Project: Research

Single-cell genomic interrogation of poor-risk Hodgkin lymphoma to annotate intraclonal heterogeneity and evolution at relapse

Project: Research

An investigation into the role of 3'UTR dynamics in breast cancer metastasis

Project: Research

Defining role of inflammatory signals in enhancing motoneuron regeneration

Project: Research

Mechanisms of mesenchymal stem cell therapy

Project: Research

Mitochondrial metabolism and its role in the maternal epigenome.

Project: Research

Evolution and specificity of alternative splicing in plants

Project: Research

A novel translational pipeline for the introduction of new immune-based therapies targeting localised and metastatic pancreatic ductal adenocarcinom

Project: Research

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Project: Research

Develoment of small molecules for neuroprotection and repair during progressive MS

Project: Research

Can mitochondrial and nuclear co-evolution drive climate adaptation?

Project: Research

An in situ structural study of Drosophila embryonic patterning

Project: Research

Design and engineering of adnectins for diagnosis and therapy

Project: Research

Promoting intestinal stem-cell mediated regeneration following damage: a critical role for Neuregulin 1

Project: Research

Transcriptional landscape of kidney epithelial cells in health and disease

Project: Research

Next generation targeting of DNA methylation to translate improved outcomes in T-cell lymphoma

Project: Research

Chasing entelechy: cell interactions and collective behaviours underlying organ growth regulation

Project: Research

The transcriptome dynamics that refine eukaryotic gene expression

Project: Research

Regulatory networks defining stem cell populations in the adult male germline

Project: Research

Linking sex-specific adaptation to the evolution of infectious disease

Project: Research

Identification and targeting of a potent NK cell “checkpoint” in tumour immunity

Project: Research

Friend or foe? Deciphering the conflicting functions of YAP in breast cancer.

Project: Research

Unravelling the role of type I Interferon family in human infectious and inflammatory diseases

Project: Research

Discovery and Characterisation of Tick Evasins - Inhibitors of Chemokine-mediated Inflammation

Project: Research

Dissecting the causes and consequences of nongenetic parental effects

Project: Research

Bacteriophage therapy increases antibiotic sensitivities in multiply antibiotic resistant Acinetobacter baumannii

Project: Research

Dying stem cells as a mechanism in mesenchymal stromal cell therapy

Project: Research

Dissecting the significance of pigment heterogeneity in cutaneous melanoma

Project: Research

Host cell death signaling and susceptibility to bacterial gut infection

Project: Research

Comprehensive risk prediction models and presymptomatic biomarkers for dementia

Project: Research

Understanding the complexity of antigen presentation

Project: Research

MIR-1: A Conserved Gatekeeper of Protein Aggregation

Project: Research

Enabling interpretation of panel tests to advance clinical practice

Project: Research

Efficacy of Smac Mimetics and the role of FOXL2 in Ovarian Cancer

Project: Research

Alzheimers and Brain Repair research

Project: Research

Genomics of antiepileptic drug-induced Stevens Johnson syndrome

Project: Research

Precision medicine for epilepsy and beyond: from discovery to implementation and evaluation

Project: Research

Australia’s native sorghums

Project: Research

Antibiotic Resistance and Host Immune Evasion in Staphylococcus aureus

Project: Research

When is hybridisation helpful or harmful to invaders?

Project: Research

Harnessing ecological and genomic approaches to restore Australian grasslands in the Project Title face of global change

Project: Research

Epigenetic regulation of telomere chromatin and genome stability

Project: Research

Plotting a Course to Tuberculosis Elimination in our Lifetime

Project: Research

Effect of clonal haematopoiesis and aspirin on outcomes in elderly: the ASPREE-HAEM study

Project: Research

Systems-level Characterisation and Therapeutic Targeting of small RNAs in Acinetobacter baumannii disease

Project: Research

A novel molecular mechanism controlling myelopoiesis

Project: Research

The Dynamics and Determinants of Plasma Cell Survival

Project: Research

Co-opting bacterial weaponry: Manipulation of the Acinetobacter type VI secretion system for targeted killing of bacteria

Project: Research

Single Cell Transcriptional analysis of vaccine induced CD8+ T cell memory

Project: Research

Investigation into epigenetic defects and new therapeutic strategy in ATRX mutated gliomas

Project: Research

Novel Ligand-Specific Interactions Enable Mineralocorticoid Receptor Modulation

Project: Research

Predicting progression risk in Multiple Sclerosis – a genotype-phenotype correlation study

Project: Research

Next-generation combination dosing strategies to combat resistant Acinetobacter baumannii

Project: Research

JDRF/NHMRC Diabetes Complications Centre of Research Excellence

Project: Research

Designing genetic rescue - a cost effective solution to save Victoria’s only endemic bird

Project: Research

A new universal mechanism controlling body proportions in animals

Project: Research

Precision Medicine for Prostate and Breast Cancer

Project: Research

Manipulating the fine-tuning of the innate immune response in disease

Project: Research

Harnessing the type VI secretion system 'combat' arsenal of A. baumannii as a source of new antimicrobials and antimicrobial targets

Project: Research

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Project: Research

G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities

Project: Research

Curing blood cancers: rapid translation from target to drug to clinic

Project: Research

New Integrated Models in the Study of Cardiac Development and Disease

Project: Research

Research Output

Coordination of cell cycle progression and mitotic spindle assembly involves histone H3 lysine 4 methylation by set1/COMPASS

Research output: Contribution to journal › Article › Research › peer-review

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

Research output: Contribution to journal › Article › Research › peer-review

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Research output: Contribution to journal › Article › Research › peer-review

RNA-seq analysis of virR and revR mutants of Clostridium perfringens

Research output: Contribution to journal › Article › Research › peer-review

Accessory subunits are integral for assembly and function of human mitochondrial complex I

Research output: Contribution to journal › Article › Research › peer-review

Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Research output: Contribution to journal › Article › Research › peer-review

Profiling DNA methylation differences between inbred mouse strains on the Illumina Human Infinium MethylationEPIC microarray

Research output: Contribution to journal › Article › Research › peer-review

αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors

Research output: Contribution to journal › Article › Research › peer-review

Dynamics of ribosome scanning and recycling revealed by translation complex profiling

Research output: Contribution to journal › Letter › Research › peer-review

The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4⁺ T-cells

Research output: Contribution to journal › Article › Research › peer-review

The RNA-binding chaperone Hfq is an important global regulator of gene expression in Pasteurella multocida and plays a crucial role in production of a number of virulence factors including hyaluronic acid capsule

Research output: Contribution to journal › Article › Research › peer-review

Concurrent host-pathogen transcriptional responses in a clostridium perfringens murine myonecrosis infection

Research output: Contribution to journal › Article › Research › peer-review

Diverse bacterial species contribute to antibiotic-associated diarrhoea and gastrointestinal damage

Research output: Contribution to journal › Article › Research › peer-review

Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination

Research output: Contribution to journal › Article › Research › peer-review

PiRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Research output: Contribution to journal › Article › Research › peer-review

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori

Research output: Contribution to journal › Article › Research › peer-review

Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines

Research output: Contribution to journal › Article › Research › peer-review

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

Research output: Contribution to journal › Article › Research › peer-review

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Research output: Contribution to journal › Article › Research › peer-review

CXCR5⁺ follicular cytotoxic T cells control viral infection in B cell follicles

Research output: Contribution to journal › Article › Research › peer-review

Computing Minimum Reaction Modifications in a Boolean Metabolic Network

Research output: Contribution to journal › Article › Research › peer-review

Age-Related Decline in Primary CD8⁺ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8⁺ T Cells

Research output: Contribution to journal › Article › Research › peer-review

Clostridium sordellii pathogenicity locus plasmid pCS1-1 encodes a novel clostridial conjugation locus

Research output: Contribution to journal › Article › Research › peer-review

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

Research output: Contribution to journal › Article › Research › peer-review

Wolbachia enhances insect-specific flavivirus infection in Aedes aegypti mosquitoes

Research output: Contribution to journal › Article › Research › peer-review

Lin-41 and oma ribonucleoprotein complexes mediate a translational repression-to-activation switch controlling oocyte meiotic maturation and the oocyte-to-embryo transition in caenorhabditis elegans

Research output: Contribution to journal › Article › Research › peer-review

The use of targeted next generation sequencing to explore candidate regulators of TGF-β1's impact on kidney cells

Research output: Contribution to journal › Article › Research › peer-review

Identification of novel Acinetobacter baumannii type VI secretion system antibacterial effector and immunity pairs

Research output: Contribution to journal › Article › Research › peer-review

miR-222 isoforms are differentially regulated by type-I interferon

Research output: Contribution to journal › Article › Research › peer-review

Trawler Web: An online de novo motif discovery tool for next-generation sequencing datasets

Research output: Contribution to journal › Article › Research › peer-review