Animal Research Platform (MARP)

Projects

Altered drug disposition in Alzheimer’s disease: impact on medicine safety

Project: Research

Epigenetic regulation of humoral immune responses.

Project: Research

High dose testosterone: Enough rope for prostate cancer cells

Project: Research

Optimizing neonatal resuscitation in the delivery room

Project: Research

A new set of targets and drugs for improving stroke outcome

Project: Other

Preventing inflammation-induced brain injury in preterm infants: targeting systemic tumour necrosis factor

Project: Research

Identification of Epigenetic Therapeutic Targets in Malignant Rhabdoid Tumour

Project: Research

Combining cell and gene therapy to develop safe and more effective designer cell-based medicine for treating MS

Project: Research

Improving survival in myelofibrosis

Project: Research

Single cell transcriptional profiling of effective flu-specific T cell immunity

Project: Research

Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

Project: Research

The role of neuronal activity in promoting remyelination of the brain

Project: Research

Defining key determinants of HLA mediated T cell tolerance and autoimmunity

Project: Research

Targeting Clec9A for Cancer immunotherapy

Project: Research

Improving cardiopulmonary resuscitation of infants in the delivery room.

Project: Research

Control of host-pathogen interactions and fungal virulence by short chain fatty acids

Project: Research

How does the brain sense low blood glucose and switch on corrective actions?

Project: Research

Optogenetic platforms and optical regulation of Oct4: light-controlled reprogramming

Project: Research

Defining the central role of podocyte depletion in the development, progression and management of glomerular disease

Project: Research

Muscle fusion as a delivery mechanism to repair ailing muscles from heritable muscle diseases

Project: Research

Plasticity of perceptual space under sensorimotor interactions

Project: Research

Understanding leukocyte function in inflammatory disease

Project: Research

Investigating the role of cognitive control in susceptibility to anorexia nervosa

Project: Research

Combating adaptive resistance to tageted therapy in triple-negative breast cancer

Project: Research

Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interaction between polymyxins and bacterial membranes

Project: Research

The neural basis of the cognitive effects of prefrontal cortex stimulation

Project: Research

Understanding adolescent neurodevelopment: relevence to schizophrenia

Project: Other

Bacterial and Host Drivers of Fulminant Community-acquired Acinetobacter baumannii Infection

Project: Research

Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

Project: Research

Anti-sporulation strategies for Clostridium difficile infections

Project: Research

Hyperleptinemia in obesity is a cause of central insulin resistance

Project: Research

Regulatory architecture of the trunk-to-tail transition

Project: Research

Exploring novel therapies for preeclampsia: the role of soluble prorenin receptor on vasculature function

Project: Research

Ghrelin receptor signaling in the brain links hunger to mood and motivation

Project: Research

Conventional and unconventional T cells in interstitial kidney disease

Project: Research

Investigating the impact of coincident modulation of adenosine and glutamate receptors on neuronal activity - implications for CNS drug discovery

Project: Research

Translating membrane proteins into therapeutics; from bedside to bench

Project: Research

Investigating Pathways of Lipoglycan Formation in the Bacterial Cell Wall

Project: Research

Novel role of inflammasomes in the molecular pathogenesis of emphysema

Project: Research

Reprogramming of adult cells for regenerative medicine therapies

Project: Research

Degradable nanocapsules for thromboprophylaxis and treatment of acute thrombosis

Project: Research

Immunomodulatory Mast Cells as Therapeutic Agents in Chronic Autoimmune and Acute Inflammatory Kidney Disease

Project: Research

Characterisation of PI3-kinase-dependent signalling networks in breast cancer

Project: Research

Regulation of phosphoinositide 3-phosphate tumour suppressor activity

Project: Research

Neural sensing of hunger links homeostatic and reward pathways

Project: Research

Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells

Project: Research

Identifying Novel Molecular Targets for Treating Chronic Pain.

Project: Research

Targeting MYC driven PC by combining targeted radionuclide therapy with ribosome biogenesis inhibition as a new therapy in CRPC and neuroendocrine PC

Project: Research

Engineering the second generation of growth factors and cytokines for regenerative medicine applications

Project: Research

Novel immune cell subsets in the CNS and supporting tissues

Project: Research

Targeting microglial potassium channels Kv1.3 for the treatment of Alzheimer's disease

Project: Research

Involvement of the claustrum in coordinating brain circuits

Project: Research

Molecular imaging and therapy of cardiac fibrosis in atrial fibrillation and heart failure

Project: Research

Representational similarity in marmoset an human visual motion processing

Project: Research

Amniotic Exosomes - Nanomedicine for Bronchopulmonary Dysplasia

Project: Research

A Cell Therapy for Necrotising Enterocolitis

Project: Research

Preventing the progressive damage to organs caused by age and cardiovasular disease

Project: Research

Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma

Project: Research

Therapeutic targeting of the colorectal epigenome

Project: Research

Novel role of innate immune DNA sensors in promoting gastric cancer

Project: Research

Novel targeting of therapy-resistant prostate cancer cells.

Project: Research

Targeting oxidant-dependent pathways to improve stroke outcomes in COPD

Project: Research

Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical Efficacy

Project: Research

Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome

Project: Research

Cells and nanobiomaterials to treat and prevent Pelvic Organ Prolapse

Project: Research

Novel treatments of fibrosis for hypertensive heart disease

Project: Research

Global regulatory networks that control virulence in Clostridium perfringens

Project: Research

Novel inhalation formulation of bacteriophages against ‘superbugs’ causing respiratory infections

Project: Research

Targeting the inflammasome; the key to curing Cerebral Palsy?

Project: Research

International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Project: Research

Development of a novel bacteriophage treatment regime to combat and re-sensitise multiply antibiotic resistant Acinetobacter baumannii infections

Project: Research

Defining the Protective Role of the Innate Immune Molecule, NLRC5, in Stomach B-cell Lymphomagenesis

Project: Research

Interferon epsilon, a key cytokine in the pathophysiology of the female reproductive tract mucosa

Project: Research

Targeting Prevention and Treatment of Hypertensive Cardiovascular Disease

Project: Research

CTXV analysis for the pipeline of CFARG airway gene therapy studies;

Project: Research

Intracellular Drug Transport

Project: Research

Hunger-sensitive neural pathways influence appetite and behaviour

Project: Research

Stem cell based strategies for re-establishing T cell immunity in aging and disease.

Project: Research

A predictive computational framework for targeted reprogramming of castrate resistant prostate cancer

Project: Research

Targeting endosomal NOX2 oxidase in viral disease

Project: Research

Examining the importance of DNA damage repair for oocyte quality, female fertility and offspring health

Project: Research

Mechanisms of mesenchymal stem cell therapy

Project: Research

Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.

Project: Research

Male contraception through pharmacological blockade of sperm transport

Project: Research

Mitochondrial metabolism and its role in the maternal epigenome.

Project: Research

Using reprogramming to generate late onset Alzheimer's disease microglia

Project: Research

Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity

Project: Research

Specific targeting of the TACE protease as a therapeutic strategy in lung adenocarcinoma and associated cachexia

Project: Research

Novel signalling pathways leading to the activation of glomerular parietal epithelial cells

Project: Research

Alcohol and Striatal Adaptation

Project: Research

Chasing entelechy: cell interactions and collective behaviours underlying organ growth regulation

Project: Research

Regulatory networks defining stem cell populations in the adult male germline

Project: Research

Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach

Project: Research

Functional disconnections in schizophrenia

Project: Research

FPR2 is a therapeutic target in lung cancer

Project: Research

A novel oncogenic alliance in breast cancer

Project: Research

Host cell death signaling and susceptibility to bacterial gut infection

Project: Research

Codon bias: a hidden layer of translational regulation by estrogens

Project: Research

Generation of human intestinal stem cells by direct reprogramming

Project: Research

The physiological and pathophysiological relevance of glucagon-like-peptide-1 receptor biased agonism

Project: Research

Pharmacological inhibition of IRAP as a novel antifibrotic strategy

Project: Research

Insulin on the Brain: Determining how insulin signalling in the brain coordinates glucose homeostasis

Project: Research

The role of NOX4 in antioxidant defence and mitochondrial biogenesis in muscle

Project: Research

Antibiotic Resistance and Host Immune Evasion in Staphylococcus aureus

Project: Research

Fetal therapy for congenital diaphragmatic hernia: a global partnership to translate surgical and cellular innovation

Project: Research

Mechanisms of manchette function.

Project: Research

Targeting cytokine signalling in systemic lupus erythematosus

Project: Research

Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approach

Project: Research

Defining the efficacy of blocking Serine phosphorylated STAT3 in the treatment of gastric cancer

Project: Research

A novel strategy for targeting castrate-resistant prostate cancer

Project: Research

Endosomal reactive oxygen species in tumour angiogenesis

Project: Research

Physiology of oxygen transport in the mammalian kidney

Project: Research

The Dynamics and Determinants of Plasma Cell Survival

Project: Research

The pulvinar is instrumental in the development of visual cortical networks

Project: Research

Improving breathing of preterm newborns exposed to inflammation during pregnancy

Project: Research

New and improved treatment strategies for neonatal seizures

Project: Research

Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-B activity

Project: Research

Molecular Genetics of Human Sexual Differentiation

Project: Research

New combination therapies for castration-resistant prostat e cancer

Project: Research

Novel strategies to improve stroke outcome

Project: Research

The role of oestrogen in the development of cardiovascular diseases in obesity

Project: Research

Antidepressants in epilepsy

Project: Research

Targeting antigen to Clec9A on dendritic cell for humoral immunity

Project: Research

A new universal mechanism controlling body proportions in animals

Project: Research

Decoding dysfunctional spinal cord circuitry in chronic pain.

Project: Research

Early life inflammation and development of cardiovascular disease

Project: Research

Harnessing the type VI secretion system 'combat' arsenal of A. baumannii as a source of new antimicrobials and antimicrobial targets

Project: Research

G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities

Project: Research

Curing blood cancers: rapid translation from target to drug to clinic

Project: Research

Targeting key regulators of innate immunity in inflammation-associated cancer

Project: Research

A biomimetic prodrug platform to enable oral bioavailability and target lymphatic disease

Project: Research

Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing

Project: Research

Adenosine Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

Project: Research

Peripheral nerve engineering

Project: Research

Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases

Project: Research

New strategies to improve personalized immunotherapy of breast cancer

Project: Other

An investigation into metabolic competition between host and pathogen in infection.

Project: Research

The vagus nerve and gut - brain interactions: the underpinnings of successful weight loss surgery through recruitment of Brown Adipose Tissue

Project: Research

A Systems Approach to the Adaptive Immune Response

Project: Research

Generation of x-linked rodent models of Alport Syndrome using CRISPR/Cas-mediated genome engineering

Project: Research

Assessing Immunogenicity of ALIOS CpG in various cancer models

Project: Research

Understanding how the Helicobacter pylori pilin protein CagL promotes gastric cancer

Project: Research

Protecting diabetic organs using a dual-acting compound delivered via injectable hydrogel

Project: Research

A Safe, Orally Administered Agent for Dengue

Project: Research

NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS

Project: Research

Examining the role of TcdB in extraintestinal damage during Clostridium difficile infection using bezlotoxumab.

Project: Research

The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

Project: Research

Tools fo Rebuilding Patient Tumours in the Laboratory

Project: Research

The Hippo Pathway And Melanoma Growth

Project: Research

The Meydan Family Foundation Diabetes Complications Research Hub

Project: Research

Muscle Fusion as a Delivery Mechanism to Repair Ailing Muscles from Heritable Muscle Diseases - FUSION

Project: Research

Can we engage weight loss circuits in the brain without causing hypertension?

Project: Research

Dual Targeting of the Androgen Receptor for Effective and Durable Control of Lethal Prostate Cancer

Project: Research

Does the ligand-RAGE axis drive small airway dysfunction in COPD?

Project: Research

Role of protein kinase D in adiposity and the regulation of body weight

Project: Research

Defining reciprocal neural circuits that regulate appetite and memory

Project: Research

The regulatory role of Clec12A in antigen presentation and inflammatory disease

Project: Research

A Peptide Derived From a Snake Venom to Treat Alzheimer's Disease

Project: Research

Multiple paths of TFH differentiation and their impact on B cell protection against infection

Project: Research

Development of a first-in-class neuroprotective drug for protecting the brain after stroke

Project: Research

2018 Al & Val Rosentrauss Fellowship

Project: Research

A neuro-immune axis regulates beige adipocyte development and function

Project: Research

IL21, B-cell Proliferation and the Mechanism of Memory Formation

Project: Research

Functional Neurogenesis in the Injured Neocortex of the Nonhuman Primate

Project: Research

Preventing and Limiting Acute Kidney Injury in High Risk Diabetic Patients

Project: Other

The importance of the blood-testis barrier in human infertility

Project: Research

Smart Targeted Nanoparticles for Diagnosis and Therapy

Project: Research

Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function

Project: Research

Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’

Project: Research

Development of small molecules for neuroprotection and repair during progressive multiple sclerosis

Project: Research

Strategies to Prevent glomerular Hyperfiltration INjury in Congenital Solitary kidneys” Acronym: SPHINCS-project

Project: Research

A therapy to restore ageing defects in egg and sperm

Project: Research

Effects of amniotic fluid ureaplasma infection, and its treatment, on brain development and

Project: Research

Does regeneration of normal-appearing myelin improve functional recovery in a mouse model of multiple sclerosis?

Project: Research

Protecting against malaria through liver-resident memory T cells

Project: Research

Unveiling the human reprogramming pathway

Project: Research

Regulation of immune responses in the adult testis and male reproductive health

Project: Research

An investigation into chromatin dynamics in host-pathogen interactions and fungal virulence

Project: Research

Understanding the roles of the EMT transcription factors in epigenetic remodelling and myeloid cell transformation.

Project: Research

Immunospheres: creating an immune system in a microparticle

Project: Research

High blood pressure and gut microbiota: mechanisms and therapeutic potential

Project: Research

G Protein-Coupled Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

Project: Research

Multiple sclerosis research in the Merson Group (ARMI)

Project: Research

Novel targeting of the glucagon family of G protein coupled receptors

Project: Research

Improving the safety and predictable efficacy of thrombolytic therapy in acute ischaemic stroke

Project: Research

The role of Il21 in B-cell activation

Project: Research

Neural computations for predictive coding in visual cortex

Project: Research

Mechanism of action of a novel multifunctional bacterial secretion system

Project: Research

Developing new treatments for severe preeclampsia

Project: Research

Defining the epigenetic origins of maternally inherited disease.

Project: Research

Integration of feedforward and feedback circuits for decision-making

Project: Research

A novel translational pipeline for the introduction of new immune-based therapies targeting localised and metastatic pancreatic ductal adenocarcinom

Project: Research

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Project: Research

Unravelling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1

Project: Research

A potential pulvinar link to Schizophrenia during development

Project: Research

Promoting intestinal stem-cell mediated regeneration following damage: a critical role for Neuregulin 1

Project: Research

New treatments to prevent acute kidney injury in high risk patients.

Project: Research

TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.

Project: Research

Bacteriophage therapy increases antibiotic sensitivities in multiply antibiotic resistant Acinetobacter baumannii

Project: Research

Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury

Project: Research

Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer

Project: Research

Dying stem cells as a mechanism in mesenchymal stromal cell therapy

Project: Research

Dissecting the significance of pigment heterogeneity in cutaneous melanoma

Project: Research

Mild traumatic brain injuries and neurodegenerative disease

Project: Research

Role of brown fat thermogenesis in sleeve gastrectomy induced improvements in glucose homeostasis

Project: Research

NHMRC Research Fellowship

Project: Research

Efficacy of Smac Mimetics and the role of FOXL2 in Ovarian Cancer

Project: Research

Alzheimers and Brain Repair research

Project: Research

Characterising the lipid droplet - mitochondria proteome

Project: Research

Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring

Project: Research

Optimising neurodevelopmental outcomes for fetal growth restriction

Project: Research

Defining the Physiology and Therapeutic Potential of Inhibin

Project: Research

The roles of STAT-1/3 in NASH and liver cancer

Project: Research

A novel molecular mechanism controlling myelopoiesis

Project: Research

Does regulation of NLRP3 by macrophage migration inhibitory factor (MIF) contribute to MS disease?

Project: Research

Finding the holy grail; "off the shelf" neural stem cell therapy for perinatal stroke

Project: Research

Discovery and development of new therapies targeting devastating human infections

Project: Consultancy

The unique nature of gamma delta T cell recognition resolved through interaction with H2-Q10

Project: Research

Novel Ligand-Specific Interactions Enable Mineralocorticoid Receptor Modulation

Project: Research

Imaging the HIV reservoir in vivo

Project: Research

A novel drug treatment that can potentially be used in all types of strokes and be given at emergency point of care

Project: Research

A novel role for proteolysis in promoting inner ear cell injury and hearing loss

Project: Research

An On Demand Bactericidal Surface to Halt Medical Device Biofouling

Project: Research

Giving prostate cancer enough rope with supraphysiologic testosterone

Project: Research

Confocal and single molecule microscopes for Systems Microscopy

Project: Other

A National Cancer Outcome Strategy

Project: Research

Finding the missing katanin required for male fertility

Project: Research

Targeting Survival programs in Acute Lymphoblastic Leukemia

Project: Research

Long-term outcomes after paediatric traumatic brain injury

Project: Research

Manipulating the fine-tuning of the innate immune response in disease

Project: Research

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Project: Research

Improving the fetal to neonatal transition in compromised newborns; towards better outcomes for babies born too soon and with under-developed lungs

Project: Research

New Integrated Models in the Study of Cardiac Development and Disease

Project: Research

Therapeutic targeting of CIMP+ Colorectal Cancers

Project: Research

Beta Cell Expansion through light stimulation of the PI3K/AKT Pathway

Project: Research

Research Output

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

Research output: Contribution to journal › Article › Research › peer-review

Mesenchymal progenitor cells primed with pentosan polysulfate promote lumbar intervertebral disc regeneration in an ovine model of microdiscectomy

Research output: Contribution to journal › Article › Research › peer-review

A novel Foxn1^eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

Research output: Contribution to journal › Article › Research › peer-review

Identification of dynamic undifferentiated cell states within the male germline

Research output: Contribution to journal › Article › Research › peer-review

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Research output: Contribution to journal › Article › Research › peer-review

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Research output: Contribution to journal › Article › Research › peer-review

Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms

Research output: Contribution to journal › Article › Research › peer-review

RABL2 is required for hepatic fatty acid homeostasis and its dysfunction leads to steatosis and a diabetes-like state

Research output: Contribution to journal › Article › Research › peer-review

An insight into intestinal mucosal microbiota disruption after stroke

Research output: Contribution to journal › Article › Research › peer-review

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Research output: Contribution to journal › Article › Research › peer-review

miR-222 isoforms are differentially regulated by type-I interferon

Research output: Contribution to journal › Article › Research › peer-review

Branching morphogenesis in the developing kidney is governed by rules that pattern the ureteric tree

Research output: Contribution to journal › Article › Research › peer-review

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Research output: Contribution to journal › Article › Research › peer-review

αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors

Research output: Contribution to journal › Article › Research › peer-review

PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells

Research output: Contribution to journal › Article › Research › peer-review

Maternal low-protein diet programmes low ovarian reserve in offspring

Research output: Contribution to journal › Article › Research › peer-review

Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation

Research output: Contribution to journal › Article › Research › peer-review

GSK3 inhibition, but not epigenetic remodeling, mediates efficient derivation of germline embryonic stem cells from nonobese diabetic mice

Research output: Contribution to journal › Article › Research › peer-review

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Research output: Contribution to journal › Article › Research › peer-review

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age

Research output: Contribution to journal › Article › Research › peer-review

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Research output: Contribution to journal › Article › Research › peer-review

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

Research output: Contribution to journal › Article › Research › peer-review

Characterization of human-like menstruation in the spiny mouse: Comparative studies with the human and induced mouse model

Research output: Contribution to journal › Article › Research › peer-review