Study Results from University of Queensland Broaden Understanding of Peptides and Proteins (Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers)

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2017 OCT 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Peptides and Proteins is the subject of a report. According to news reporting out of St. Lucia, Australia, by NewsRx editors, research stated, "PEGylated polylysine dendrimers are attractive and well tolerated inhalable drug delivery platforms that have the potential to control the release, absorption kinetics and lung retention time of conjugated drugs. The clinical application of these systems though, would likely require partial substitution of surface PEG groups with drug molecules that are anticipated to alter their lung clearance kinetics and clearance pathways."

Our news journalists obtained a quote from the research from the University of Queensland, "In the current study, we therefore evaluated the impact of increased surface hydrophobicity via substitution of 50% surface PEG groups with a model hydrophobic drug (alpha-carboxyl OtButylated methotrexate) on the lung clearance of a Generation 5 PEGylated polylysine dendrimer in rats. PEG substitution with OtBu-methotrexate accelerated lung clearance of the dendrimer by increasing polylysine scaffold catabolism, improving systemic absorption of the intact dendrimer and low molecular weight products of scaffold catabolism, and enhancing mucociliary clearance."

According to the news editors, the research concluded: "These results suggest that the conjugation of hydrophobic drug on the surface of a PEGylated dendrimer is likely to accelerate lung clearance when compared to a fully PEGylated dendrimer."

For more information on this research see: Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics, 2017;119():408-418. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.journals.elsevier.com/european-journal-of-pharmaceutics-and-biopharmaceutics/)

Our news journalists report that additional information may be obtained by contacting L.M. Kaminskas, University of Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia. Additional authors for this research include V.M. McLeod, S. Jones, S. Fung, M. Whittaker, M. McIntosh, C. Pouton, D.J. Owen, C.J.H. Porter and S. Haque.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ejpb.2017.07.005. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: St. Lucia, Australia, Australia and New Zealand, Amino Acids, Drugs and Therapies, Peptides and Proteins, Polylysine, Lysine, University of Queensland.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

The citation for this news report is: NewsRx. Study Results from University of Queensland Broaden Understanding of Peptides and Proteins (Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers). Obesity, Fitness & Wellness Week. October 28, 2017; p 4081.

Period28 Oct 2017

Media coverage

1

Media coverage

  • TitleStudy Results from University of Queensland Broaden Understanding of Peptides and Proteins (Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers)
    Degree of recognitionInternational
    Media name/outlet Obesity, Fitness & Wellness Week/NewsRx
    Media typePrint
    CountryUnited States of America
    Date28/10/17
    Description 2017 OCT 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Peptides and Proteins is the subject of a report. According to news reporting out of St. Lucia, Australia, by NewsRx editors, research stated, "PEGylated polylysine dendrimers are attractive and well tolerated inhalable drug delivery platforms that have the potential to control the release, absorption kinetics and lung retention time of conjugated drugs. The clinical application of these systems though, would likely require partial substitution of surface PEG groups with drug molecules that are anticipated to alter their lung clearance kinetics and clearance pathways." Our news journalists obtained a quote from the research from the University of Queensland, "In the current study, we therefore evaluated the impact of increased surface hydrophobicity via substitution of 50% surface PEG groups with a model hydrophobic drug (alpha-carboxyl OtButylated methotrexate) on the lung clearance of a Generation 5 PEGylated polylysine dendrimer in rats. PEG substitution with OtBu-methotrexate accelerated lung clearance of the dendrimer by increasing polylysine scaffold catabolism, improving systemic absorption of the intact dendrimer and low molecular weight products of scaffold catabolism, and enhancing mucociliary clearance." According to the news editors, the research concluded: "These results suggest that the conjugation of hydrophobic drug on the surface of a PEGylated dendrimer is likely to accelerate lung clearance when compared to a fully PEGylated dendrimer." For more information on this research see: Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics, 2017;119():408-418. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.journals.elsevier.com/european-journal-of-pharmaceutics-and-biopharmaceutics/) Our news journalists report that additional information may be obtained by contacting L.M. Kaminskas, University of Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia. Additional authors for this research include V.M. McLeod, S. Jones, S. Fung, M. Whittaker, M. McIntosh, C. Pouton, D.J. Owen, C.J.H. Porter and S. Haque. The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ejpb.2017.07.005. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation. Keywords for this news article include: St. Lucia, Australia, Australia and New Zealand, Amino Acids, Drugs and Therapies, Peptides and Proteins, Polylysine, Lysine, University of Queensland. Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC The citation for this news report is: NewsRx. Study Results from University of Queensland Broaden Understanding of Peptides and Proteins (Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers). Obesity, Fitness & Wellness Week. October 28, 2017; p 4081.
    URLhttps://go.gale.com/ps/i.do?&id=GALE|A510836444&v=2.1&u=monash&it=r&p=AONE&sw=w
    PersonsShadab Haque