Studies from Monash University Have Provided New Data on Liposomes (Local Inflammation Alters the Lung Disposition of a Drug Loaded Pegylated Liposome After Pulmonary Dosing To Rats)

Press/Media: Article/Feature

Period12 Oct 2019

Media coverage

1

Media coverage

  • TitleStudies from Monash University Have Provided New Data on Liposomes (Local Inflammation Alters the Lung Disposition of a Drug Loaded Pegylated Liposome After Pulmonary Dosing To Rats)
    Degree of recognitionInternational
    Media name/outletObesity, Fitness & Wellness Week
    Media typePrint
    Country/TerritoryUnited States of America
    Date12/10/19
    Description2019 OCT 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Biotechnology - Liposomes are presented in a new report. According to news reporting originating in Parkville, Australia, by NewsRx journalists, research stated, "The development of inhalable 'nanomedicines' based on biocompatible lipids and polymers is attracting increasing interest worldwide. Our understanding of how pulmonary inflammation impacts on lung distribution and clearance kinetics however, is limited." Funders for this research include VIDS postgraduate scholarship, NHMRC Career Development fellowship, NHMRC Project Grant. The news reporters obtained a quote from the research from Monash University, "Similarly, there is limited information on how the inhaled delivery of biocompatible nanomaterials affects existing respiratory disease. We have addressed these knowledge gaps by describing and comparing the pulmonary pharmacokinetic behaviour of a H-3-labelled PEGylated liposome loaded with a model drug (ciprofloxacin) after intratracheal administration to healthy rats and rats with bleomycin-induced lung inflammation by following both H-3 label and drug. Cell-and cytokine-based markers of lung inflammation were used to evaluate the response of healthy and inflamed lungs to the liposome. Liposomes were initially cleared more rapidly from inflamed lungs than from healthy lungs, but exhibited similar rates of lung clearance after 3 days. This was interesting given that mucociliary clearance was more efficient from healthy lungs, despite evidence of higher mucus retention in inflamed lungs and reduced association of the liposome with lung tissue. Although the plasma pharmacokinetics of ciprofloxacin did not differ between rats with healthy or inflamed lungs after pulmonary administration, the plasma pharmacokinetics of H-3-phosphatidylcholine suggested higher liposome bioavailability and more prolonged absorption from inflamed lungs." According to the news reporters, the research concluded: "Concentrations of the pro-inflammatory cytokine IL-1 beta were increased in bronchoalveolar lavage fluid after a single pulmonary dose of liposomes to rats with inflamed lungs, but no other significant changes in lung inflammatory markers were identified in healthy or bleomycin-challenged rats." For more information on this research see: Local Inflammation Alters the Lung Disposition of a Drug Loaded Pegylated Liposome After Pulmonary Dosing To Rats. Journal of Controlled Release, 2019;307():32-43. Journal of Controlled Release can be contacted at: Elsevier, Radarweg 29, 1043 Nx Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.journals.elsevier.com/journal-of-controlled-release/) Our news correspondents report that additional information may be obtained by contacting L.M. Kaminskas, Monash University, Drug Delivery Disposit & Dynam, Monash Institute of Pharmaceutical Sciences, 381 Royal Pde, Parkville, Vic 3052, Australia. Additional authors for this research include S. Haque, O. Feeney, B. Boyd, M.P. McIntosh, C.W. Pouton, M. Whittaker and E. Meeusen. Keywords for this news article include: Parkville, Australia, Australia and New Zealand, Biotechnology, Drug Delivery Systems, Drugs and Therapies, Health and Medicine, Heparin Therapy, Inflammation, Liposomes, Pharmaceuticals, Pharmacokinetics, Pharmacology, Monash University. Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2019, NewsRx LLC The citation for this news report is: NewsRx. Studies from Monash University Have Provided New Data on Liposomes (Local Inflammation Alters the Lung Disposition of a Drug Loaded Pegylated Liposome After Pulmonary Dosing To Rats). Obesity, Fitness & Wellness Week. October 12, 2019; p 672.
    URLhttps://go.gale.com/ps/i.do?id=GALE%7CA601854668&v=2.1&u=monash&it=r&p=AONE&sw=w
    PersonsShadab Haque