Scientists reveal 'superbug's' artillery

Press/Media: Research

Description


Dr Iain Hay from Monash Biomedicine Discovery Institute

Published recently in mBio, and with media coverage including reports on PhysOrgICT Today Bright Surf and DotMed,a study led by Monash BDI's Professor Trevor Lithgow and Dr Iain Hay has created the first high-resolution structure depicting a crucial part of the ‘superbug’ Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image, developed using the Titan Krios microscope, identifies the ‘nanomachine’ used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.

Period19 Oct 2017 → 20 Oct 2017

Media coverage

5

Media coverage

  • TitleResearchers Reveal How Superbug Secretes It’s Toxin
    Degree of recognitionInternational
    Media name/outletTechnology Networks
    Media typeWeb
    CountryAustralia
    Date20/10/17
    DescriptionMonash University’s Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the ‘superbug’ Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image identifies the ‘nanomachine’ used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.

    P. aeruginosa is one of a number of bacteria developing an alarming resistance to multiple drugs, raising concerns worldwide about the emergence of pan-resistant organisms.

    Its virulence is due largely to the ability of the bacteria to secrete a suite of toxins and enzymes infecting the host environment.
    URLhttps://www.technologynetworks.com/drug-discovery/news/researchers-reveal-how-superbug-secretes-its-toxin-293437
    PersonsIain Hay
  • TitleScientists reveal 'superbug's' artillery
    Degree of recognitionInternational
    Media name/outletbright surf
    CountryAustralia
    Date19/10/17
    DescriptionMonash University's Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the 'superbug' Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image identifies the 'nanomachine' used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.

    P. aeruginosa is one of a number of bacteria developing an alarming resistance to multiple drugs, raising concerns worldwide about the emergence of pan-resistant organisms.

    Its virulence is due largely to the ability of the bacteria to secrete a suite of toxins and enzymes infecting the host environment.

    In a paper published this week in the online journal mBio, BDI researchers investigated a protein nanomachine on the surface of the bacterial cells responsible for the secretion of these toxins. The nanomachine, called the Type II secretion system, is responsible for the secretion of P. aureginosa's most toxic virulence factor, Exotoxin A.
    URLhttps://www.brightsurf.com/news/article/101917441743/scientists-reveal-superbugs-artillery.html
    PersonsIain Hay
  • TitleScientists create the first high-resolution structure depicting superbug's artillery
    Degree of recognitionInternational
    CountryAustralia
    Date19/10/17
    DescriptionMonash University's Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the 'superbug' Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image identifies the 'nanomachine' used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.
    URLhttps://www.dotmed.com/news/story/39801
    PersonsIain Hay
  • Titlehttps://phys.org/news/2017-10-scientists-reveal-superbug-artillery.html
    Degree of recognitionInternational
    Media name/outletPhys.org
    CountryAustralia
    Date19/10/17
    DescriptionMonash University's Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the 'superbug' Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image identifies the 'nanomachine' used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.

    Read more at: https://phys.org/news/2017-10-scientists-reveal-superbug-artillery.html#jCp
    URLhttps://phys.org/news/2017-10-scientists-reveal-superbug-artillery.html
    PersonsTrevor Lithgow
  • TitleScientists Reveal Superbug's Artillery
    Degree of recognitionInternational
    Media name/outletInfection Control Today
    CountryAustralia
    Date19/10/17
    DescriptionOct 19, 2017


    Monash University's Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the 'superbug' Pseudomonas aeruginosa, classified by the WHO as having the highest level threat to human health. The image identifies the 'nanomachine' used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.
    URLhttps://www.infectioncontroltoday.com/pathogens/scientists-reveal-superbugs-artillery
    PersonsIain Hay

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