Pharmacokinetics; Research Findings from Jawaharlal Nehru University Update Understanding of Pharmacokinetics

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2012 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Pharmacokinetics have been published. According to news reporting from New Delhi, India, by NewsRx journalists, researchers stated "The purpose of the present investigation was to prepare venlafaxine (VLF) loaded chitosan nanoparticles (NPs) to enhance the uptake of VLF to brain via intranasal (in.) delivery. VLF loaded chitosan NPs were prepared and characterized for particle size, size distribution, zeta potential, encapsulation efficiency and in vitro drug release."

The news correspondents obtained a quote from the research by the authors from Jawaharlal Nehru University, "In order to investigate the localization of chitosan NPs in brain and other organs qualitatively confocal laser scanning microscopy technique was carried out using rhodamine-123 (ROD-123) as marker. The levels of VLF in plasma and brain tissues were also determined, the brain/blood ratios of VLF for VLF (i.v.), VLF (i.n.), VLF chitosan NPs (in.) were 0.0293, 0.0700 and 0.1612, respectively, at 0.5 h, indicative of better brain uptake of VLF chitosan NPs."

According to the news reporters, the researchers concluded: "The higher drug transport efficiency (508.59) and direct transport percentage (80.34) of VLF chitosan NPs as compared to other formulations suggest its better efficacy in treatment of depression."

For more information on this research see: Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation. Carbohydrate Polymers, 2012;89(1):72-79. Carbohydrate Polymers can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)

Our news journalists report that additional information may be obtained by contacting S. Haque, Jawaharlal Nehru Univ, Adv Instrumentat Res Facil, New Delhi 110067, India.

Keywords for this news article include: Asia, Pharmaceuticals, India, Drugs, Therapy, New Delhi, Pharmacodynamics, Pharmacokinetics

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2012, NewsRx LLC

Period7 Jul 2012

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  • TitlePharmacokinetics; Research Findings from Jawaharlal Nehru University Update Understanding of Pharmacokinetics
    Degree of recognitionInternational
    Media name/outletObesity, Fitness & Wellness Week/NewsRx
    Media typePrint
    CountryUnited States of America
    Date7/07/12
    Description2012 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Pharmacokinetics have been published. According to news reporting from New Delhi, India, by NewsRx journalists, researchers stated "The purpose of the present investigation was to prepare venlafaxine (VLF) loaded chitosan nanoparticles (NPs) to enhance the uptake of VLF to brain via intranasal (in.) delivery. VLF loaded chitosan NPs were prepared and characterized for particle size, size distribution, zeta potential, encapsulation efficiency and in vitro drug release." The news correspondents obtained a quote from the research by the authors from Jawaharlal Nehru University, "In order to investigate the localization of chitosan NPs in brain and other organs qualitatively confocal laser scanning microscopy technique was carried out using rhodamine-123 (ROD-123) as marker. The levels of VLF in plasma and brain tissues were also determined, the brain/blood ratios of VLF for VLF (i.v.), VLF (i.n.), VLF chitosan NPs (in.) were 0.0293, 0.0700 and 0.1612, respectively, at 0.5 h, indicative of better brain uptake of VLF chitosan NPs." According to the news reporters, the researchers concluded: "The higher drug transport efficiency (508.59) and direct transport percentage (80.34) of VLF chitosan NPs as compared to other formulations suggest its better efficacy in treatment of depression." For more information on this research see: Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation. Carbohydrate Polymers, 2012;89(1):72-79. Carbohydrate Polymers can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871) Our news journalists report that additional information may be obtained by contacting S. Haque, Jawaharlal Nehru Univ, Adv Instrumentat Res Facil, New Delhi 110067, India. Keywords for this news article include: Asia, Pharmaceuticals, India, Drugs, Therapy, New Delhi, Pharmacodynamics, Pharmacokinetics Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2012, NewsRx LLC
    URLhttps://search.proquest.com/docview/1022329318?accountid=12528&rfr_id=info%3Axri%2Fsid%3Aprimo
    PersonsShadab Haque