New treatment target for endometriosis

Press/Media: Article/Feature


Editorial in Nature Reviews Endocrinology

Period10 Sept 2021

Media coverage


Media coverage

  • TitleNew treatment target for endometriosis
    Degree of recognitionInternational
    Media name/outletNature Reviews Endocrinology
    Media typePrint
    Country/TerritoryUnited Kingdom
    DescriptionThere are very few treatment options for people with endometriosis, an inflammatory condition that causes pelvic pain and can be debilitating. In a new study, researchers sequenced DNA from 32 families with a history of endometriosis. They identified a genetic linkage signal on chromosome 7p13–15. There was also overrepresentation of deleterious coding variants in NPSR1 (which encodes neuropeptide S receptor 1) in people with endometriosis. These findings were replicated in a cohort of rhesus macaques with spontaneous endometriosis. Further work in a cohort of people with or without endometriosis revealed that variant rs142885915 was associated with stage III or IV endometriosis. NPSR1 was found to be expressed in glandular epithelium from eutopic and ectopic endometrium. In addition, mouse models of peritoneal inflammation or endometriosis were treated with an inhibitor of NPSR1, which reduced peritoneal inflammation and pelvic pain. The authors suggest that the NPSR1 system could be a nonhormonal target for treating endometriosis.
    Producer/AuthorClaire Greenhill
    PersonsThomas Tapmeier


  • Endometriosis