Media contributions
1Media contributions
Title Frozen in action: cryo-EM structure of a GPCR–G-protein complex Degree of recognition International Media name/outlet Nature Structural & Molecular Biology Media type Print Date 6/06/17 Description Comment on:
Furness SGB, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A,
Christopoulos A, Wootten D, Sexton PM. Ligand-Dependent Modulation of G Protein
Conformation Alters Drug Efficacy. Cell. 2016 Oct 20;167(3):739-749.e11. doi:
10.1016/j.cell.2016.09.021. Epub 2016 Oct 6. PubMed PMID: 27720449.
Abstract:
Interaction with heterotrimeric G proteins is a hallmark of G-protein-coupled receptor (GPCR) family members, and it is the key step for a diverse range of cell-signaling cascades. A recent cryo-EM structure of the human calcitonin receptor (CTR) in complex with a G-protein heterotrimer reveals novel insights into receptor–G-protein couplingProducer/Author Nature Structural & Molecular Biology URL https://www.nature.com/articles/nsmb.3418 Persons Sebastian Furness