Frozen in action: cryo-EM structure of a GPCR–G-protein complex

Press/Media: Expert Comment

Description

Commentary on:

Furness SGB, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D, Sexton PM. Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy. Cell. 2016 Oct 20;167(3):739-749.e11. doi: 10.1016/j.cell.2016.09.021. Epub 2016 Oct 6. PubMed PMID: 27720449.

 

Period6 Jun 2017

Media contributions

1

Media contributions

  • TitleFrozen in action: cryo-EM structure of a GPCR–G-protein complex
    Degree of recognitionInternational
    Media name/outletNature Structural & Molecular Biology
    Media typePrint
    Date6/06/17
    DescriptionComment on:
    Furness SGB, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A,
    Christopoulos A, Wootten D, Sexton PM. Ligand-Dependent Modulation of G Protein
    Conformation Alters Drug Efficacy. Cell. 2016 Oct 20;167(3):739-749.e11. doi:
    10.1016/j.cell.2016.09.021. Epub 2016 Oct 6. PubMed PMID: 27720449.



    Abstract:

    Interaction with heterotrimeric G proteins is a hallmark of G-protein-coupled receptor (GPCR) family members, and it is the key step for a diverse range of cell-signaling cascades. A recent cryo-EM structure of the human calcitonin receptor (CTR) in complex with a G-protein heterotrimer reveals novel insights into receptor–G-protein coupling
    Producer/AuthorNature Structural & Molecular Biology
    URLhttps://www.nature.com/articles/nsmb.3418
    PersonsSebastian Furness