Title F1000 recommendation Degree of recognition International Media name/outlet F1000 Media type Web Date 16/06/16 Description his is an exceptionally thorough study, which combines site-directed mutagenesis, molecular modeling, in vitro signaling and molecular dynamics studies to arrive at a three-dimensional representation of key residues implicated in biased agonism at the GLP-1 (glucagon-like peptide 1) receptor. As GLP-1 agonists continue to represent therapeutics for a variety of metabolic disorders, understanding the molecular and eventually atomic mechanisms for biased signaling and functional selectivity at this receptor has important theoretical and therapeutic implications.
Going forward, it will be important to correlate these findings with direct biophysical and structural studies of GLP-1R.
Roth B: F1000Prime Recommendation of [Wootten D et al., Cell 2016 165(7):1632-1643]. In F1000Prime, 11 Oct 2016; 10.3410/f.726430827.793523956
Producer/Author Brian Roth URL https://f1000.com/prime/726430827 Persons Sebastian Furness