F1000 Prime recommendation

Press/Media: Article/Feature

Period9 Sep 2020

Media coverage

1

Media coverage

  • TitleF1000 Prime recommendation
    Media name/outletFaculty of 1000
    Media typeWeb
    CountryAustralia
    Date9/09/20
    DescriptionThe recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics.
    Producer/AuthorF1000
    URLhttps://facultyopinions.com/prime/737578843#tab=abstract
    PersonsNaveen Vankadari