BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Description

Research led by Monash BDI’s Professor Benjamin Kile has received national and international media coverage, including publication in The Age, the Sun Herald, Sydney Morning Herald (and other Fairfax outlets), Medindia, Brightsurf, Medianet, Medical Express , Public Now, and Lab Online. Professor Kile was also interviewed by Elizabeth Jackson on ABC Radio AM.

The team discovered - and filmed - the exact moment when DNA escapes out of the mitochondria (the organelles inside cells that produce energy) during cell death. The study, published in the journal Science, involved major collaborators from the Walter and Eliza Hall Institute and the Howard Hughes Medical Institute's Janelia Research Campus in the US.

Published in Science  23 Feb 2018:
Vol. 359, Issue 6378, eaao6047
DOI: 10.1126/science.aao6047