BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Press/Media: Research


Research led by Monash BDI’s Professor Benjamin Kile has received national and international media coverage, including publication in The Age, the Sun Herald, Sydney Morning Herald (and other Fairfax outlets), MedindiaBrightsurfMedianetMedical Express Public Now, and Lab Online. Professor Kile was also interviewed by Elizabeth Jackson on ABC Radio AM.

The team discovered - and filmed - the exact moment when DNA escapes out of the mitochondria (the organelles inside cells that produce energy) during cell death. The study, published in the journal Science, involved major collaborators from the Walter and Eliza Hall Institute and the Howard Hughes Medical Institute's Janelia Research Campus in the US.

Published in Science  23 Feb 2018:
Vol. 359, Issue 6378, eaao6047
DOI: 10.1126/science.aao6047


Period24 Feb 2018 → 23 Aug 2018

Media coverage


Media coverage

Media contributions


Media contributions

  • TitleNew treatments discovered for arthritis and lupus
    Media name/outletABC News AM Radio
    DescriptionResearchers in Melbourne have made a significant discovery which could lead to new treatments for autoimmune diseases such as arthritis and lupus. The scientists have identified the process through which DNA is transferred from individual cells into the body's bloodstream. It all starts with the mitochondria, the powerhouse of your cells.
    Producer/AuthorElizabeth Jackson
    PersonsBenjamin Kile


  • Kile
  • cell death
  • mitochondrial DNA
  • apoptosis
  • ABC