Norwood Immunology, Ltd. (External organisation)

  • Ann P. Chidgey (Inventor)
  • Jayne Suzanne Sutherland (Inventor)
  • Gabrielle Lianne Goldberg (Inventor)
  • Richard Boyd (Inventor)

Activity: Industry, Government and Philanthropy Engagement and PartnershipsPatentsPatent

Description

Tolerance to graft prior to thymic regeneration
WO2004094988A3 - WIPO (PCT)
Abstract: The present disclosure provides methods for inducing tolerance in a recipient to a mismatched graft of an organ, tissue, and/or cells, by disrupting sex steroid signaling in the patient, wherein the bone marrow and other immune cell functionality is improved without, prior to, or concurrently with, thymic regeneration. In some embodiments, sex steroid signaling in the patient, is interrupted or ablated by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof.
Period4 Nov 2004
Held atNorwood Immunology, Ltd., Australia
Degree of RecognitionInternational