Medicines for Malaria Venture (MMV) (External organisation)

  • Jonathan Vennerstrom (Inventor)
  • Yuxiang Dong (Inventor)
  • Charman, S. A. (Inventor)
  • Sergio Wittlin (Inventor)
  • Jacques Chollet (Inventor)
  • Creek, D. J. (Inventor)
  • Xiaofang Wang (Inventor)
  • Kamaraj Sriraghavan (Inventor)
  • Lin Zhou (Inventor)
  • Hugues Matile (Inventor)
  • Charman, W. N. (Inventor)

Activity: Industry, Government and Philanthropy Engagement and PartnershipsPatentsPatent

Description

Dispiro 1,2,4-trioxolane antimalarials
US8067620B2 - United States

Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.
Period29 Nov 2011
Held atMedicines for Malaria Venture (MMV), Switzerland
Degree of RecognitionNational